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Substance Name: Epinastine hydrochloride [JAN]
RN: 108929-04-0
UNII: GFM415S5XL
InChIKey: VKXSGUIOOQPGAF-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C16-H15-N3.Cl-H

Molecular Weight

  • 285.7764
 
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Names and Synonyms

Name of Substance

  • Epinastine hydrochloride
  • Epinastine hydrochloride [JAN]

Synonyms

  • 3-Amino-9,13b-dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepine monohydrochloride
  • Alesion
  • Elestat
  • Epinastine HCl
  • Epinastine monohydrochloride
  • UNII-GFM415S5XL
  • WAL 801 CL

Systematic Name

  • IH-Dibenz(c,f)imidazo(1,5-a)azepin-3-amine, 9,13b-dihydro-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 108929-04-0

FDA UNII

  • GFM415S5XL

Other Registry Number

  • 80012-44-8

Related Registry Number

  • 80012-43-7 (Parent)

System Generated Number

  • 0108929040

Molecular Formulas

Molecular Formula

  • C16-H15-N3.Cl-H

Molecular Formula Fragments

  • C16-H15-N3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C16H15N3.ClH/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16;/h1-8,15H,9-10H2,(H2,17,18);1H

InChIKey

VKXSGUIOOQPGAF-UHFFFAOYSA-N

Smiles

N12C(c3c(Cc4c1cccc4)cccc3)CN=C2N.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 200mg/kg (200mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BLOOD: HEMORRHAGE
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 2166, 1994.
rat LD50 intravenous 17mg/kg (17mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 151, 1991.
rat LD50 oral 192mg/kg (192mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 151, 1991.