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Substance Name: 2-Methoxyethanol
RN: 109-86-4
UNII: EK1L6XWI56
InChIKey: XNWFRZJHXBZDAG-UHFFFAOYSA-N

Note

  • Widely used industrial solvent for resins, lacquers, dyes & inks; may cause anemia macrocytosis, appearance of young granulocytes in blood.

Molecular Formula

  • C3-H8-O2

Molecular Weight

  • 76.0942
 

Classification Codes

Classification Codes

  • Human Data
  • Immunologic Factors
  • Immunosuppressive Agents
  • Mutation Data
  • Noxae
  • Reproductive Effect
  • Skin / Eye Irritant
  • Teratogens
  • TSCA Flag S (Substance is Identified in a Final Significant New Use Rule)
  • Tumor Data

Superlist Classification Codes

  • TWA 25 ppm (80 mg/m3); skin
  • TWA 5 ppm; skin; BEI

Names and Synonyms

Name of Substance

  • 2-Methoxyethanol
  • Ethanol, 2-methoxy-
  • Ethylene glycol monomethyl ether
  • Methyl cellosolve
  • Monomethyl ethylene glycol ether

Synonyms

  • 1-Hydroxy-2-methoxyethane
  • 2-Methoxy-1-ethanol
  • 2-Methoxy-aethanol
  • 2-Methoxy-aethanol [German]
  • 2-Methoxyethanol
  • 2-Methoxyethyl alcohol
  • 2-Metossietanolo
  • 2-Metossietanolo [Italian]
  • 3-Oxa-1-butanol
  • 4-01-00-02375 (Beilstein Handbook Reference)
  • Aethylenglykol-monomethylaether
  • Aethylenglykol-monomethylaether [German]
  • AI3-18363
  • Amsco-Solv EE
  • BRN 1731074
  • Caswell No. 551
  • CCRIS 5826
  • Dowanol 7
  • Dowanol EM
  • EC 203-713-7
  • EGME
  • EINECS 203-713-7
  • EPA Pesticide Chemical Code 042202
  • Ethanol, 2-methoxy-
  • Ether monomethylique de l'ethylene-glycol
  • Ether monomethylique de l'ethylene-glycol [French]
  • Ethylene glycol methyl ether
  • Ethylene glycol monomethyl ether
  • Ethyleneglycol monomethyl ether
  • Glycol ether EM
  • Glycol monomethyl ether
  • HSDB 97
  • Jeffersol EM
  • MECS
  • Methoxyhydroxyethane
  • Methyl cellosolve
  • Methyl glycol
  • Methyl oxitol
  • Methylcelosolv
  • Methylcelosolv [Czech]
  • Methylglykol
  • Methylglykol [German]
  • Metil cellosolve
  • Metil cellosolve [Italian]
  • Metoksyetylowy alkohol
  • Metoksyetylowy alkohol [Polish]
  • Monoethylene glycol methyl ether
  • Monomethyl ether of ethylene glycol
  • Monomethyl glycol
  • NSC 1258
  • Poly-Solv EM
  • Prist
  • UNII-EK1L6XWI56

Systematic Names

  • 2-Methoxyethanol
  • Ethanol, 2-methoxy-

Superlist Names

  • 2-Methoxyethanol
  • EGME
  • Ethanol, 2-methoxy-
  • Ethylene glycol methyl ether
  • Ethylene glycol monomethyl ether
  • Ethylene glycol monomethyl ether [UN1188] [Flammable liquid]
  • Methyl cellosolve
  • UN1188

Registry Numbers

CAS Registry Number

  • 109-86-4

FDA UNII

  • EK1L6XWI56

Related Registry Numbers

  • 28099-67-4 (calcium salt)
  • 3139-99-9 (hydrochloride salt)

System Generated Number

  • 0000109864

Structure Descriptors

InChI

1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3

InChIKey

XNWFRZJHXBZDAG-UHFFFAOYSA-N

Smiles

C(CO)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 950mg/kg (950mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

GASTROINTESTINAL: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
human LDLo oral 3380mg/kg (3380mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

GASTROINTESTINAL: GASTRITIS

LIVER: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 28, Pg. 267, 1946.
human TCLo inhalation 25ppm (25ppm) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Journal of Industrial Hygiene and Toxicology. Vol. 20, Pg. 134, 1938.
mouse LC50 inhalation 1480ppm/7H (1480ppm) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

KIDNEY, URETER, AND BLADDER: HEMATURIA

BEHAVIORAL: ANALGESIA
Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 157, 1943.
mouse LD50 intraperitoneal 2147mg/kg (2147mg/kg) BLOOD: CHANGES IN SPLEEN

BLOOD: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947.
mouse LD50 oral 2560mg/kg (2560mg/kg) CARDIAC: OTHER CHANGES

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(3), Pg. 48, 1988.
rabbit LD50 oral 890mg/kg (890mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA
AMA Archives of Industrial Health. Vol. 14, Pg. 114, 1956.
rabbit LD50 skin 1280mg/kg (1280mg/kg)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 57, 1974.
rat LC50 inhalation 1500ppm/7H (1500ppm)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 57, 1974.
rat LD50 intraperitoneal 2500mg/kg (2500mg/kg)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 57, 1974.
rat LD50 intravenous 2068mg/kg (2068mg/kg) BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA AMA Archives of Industrial Health. Vol. 14, Pg. 114, 1956.
rat LD50 oral 2370mg/kg (2370mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Veterinary and Human Toxicology. Vol. 29, Pg. 361, 1987.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -8.51E+01 deg C   EXP
Boiling Point 124.1 deg C   EXP
pKa Dissociation Constant 14.8 (none) 25 EXP
log P (octanol-water) -0.77 (none)   EXP
Water Solubility 1.00E+06 mg/L 25 EXP
Vapor Pressure 9.5 mm Hg 25 EXP
Henry's Law Constant 3.30E-07 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 1.25E-11 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.