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Substance Name: Tetrahydrofuran
RN: 109-99-9
UNII: 3N8FZZ6PY4
InChIKey: WYURNTSHIVDZCO-UHFFFAOYSA-N

Molecular Formula

  • C4-H8-O

Molecular Weight

  • 72.1062
 

Classification Codes

Classification Codes

  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Tumor Data

Superlist Classification Codes

  • Reportable Quantity (RQ) = 1000 lb
  • TWA 200 ppm (590 mg/m3)
  • TWA 50 ppm; STEL 100 ppm; Skin; Confirmed animal carcinogen with unknown relevance to humans

Names and Synonyms

Name of Substance

  • Tetrahydrofuran

Synonyms

  • 1,4-Epoxybutane
  • Agrisynth THF
  • AI3-07570
  • Butane, 1,4-epoxy-
  • Butane, alpha,delta-oxide
  • Butylene oxide
  • CCRIS 6276
  • Cyclotetramethylene oxide
  • Diethylene oxide
  • EC 203-726-8
  • EINECS 203-726-8
  • Furan, tetrahydro-
  • Furanidine
  • HSDB 125
  • Hydrofuran
  • NCI-C60560
  • NSC 57858
  • Oxacyclopentane
  • Oxolane
  • RCRA waste number U213
  • Tetrahydrofuraan
  • Tetrahydrofuraan [Dutch]
  • Tetrahydrofuran
  • Tetrahydrofuranne
  • Tetrahydrofuranne [French]
  • Tetraidrofurano
  • Tetraidrofurano [Italian]
  • Tetramethylene oxide
  • THF
  • UNII-3N8FZZ6PY4

Systematic Names

  • Furan, tetrahydro-
  • Tetrahydrofuran

Superlist Names

  • Furan, tetrahydro-
  • RCRA waste no. U213
  • Tetrahydrofuran
  • Tetrahydrofuran [UN2056] [Flammable liquid]
  • UN2056

Registry Numbers

CAS Registry Number

  • 109-99-9

FDA UNII

  • 3N8FZZ6PY4

Other Registry Number

  • 77392-70-2

System Generated Number

  • 0000109999

Structure Descriptors

InChI

1S/C4H8O/c1-2-4-5-3-1/h1-4H2

InChIKey

WYURNTSHIVDZCO-UHFFFAOYSA-N

Smiles

C1CCOC1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 2300mg/kg (2300mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 34(9), Pg. 114, 1969.
guinea pig LDLo intraperitoneal 500mg/kg (500mg/kg) LIVER: FATTY LIVER DEGERATION American Industrial Hygiene Association Journal. Vol. 35, Pg. 21, 1974.
human TCLo inhalation 25000ppm (25000ppm) BEHAVIORAL: GENERAL ANESTHETIC "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 580, 1969.
mouse LCLo inhalation 24000mg/m3/2H (24000mg/m3) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE WEAKNESS
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 5, Pg. 21, 1963.
mouse LD50 intraperitoneal 1900mg/kg (1900mg/kg)   Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 24, Pg. 373, 1982.
rabbit LC inhalation > 1200ppm/4H (1200ppm) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION Sumitomo Sangyo Eisei. Sumitomo Industrial Health. Vol. 18, Pg. 89, 1982.
rat LC50 inhalation 21000ppm/3H (21000ppm) BEHAVIORAL: SLEEP

GASTROINTESTINAL: NAUSEA OR VOMITING

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Sumitomo Sangyo Eisei. Sumitomo Industrial Health. Vol. 20, Pg. 141, 1984.
rat LD50 intraperitoneal 2900mg/kg (2900mg/kg)   Sangyo Igaku. Japanese Journal of Industrial Health. Vol. 24, Pg. 373, 1982.
rat LD50 oral 1650mg/kg (1650mg/kg)   GAF Material Safety Data Sheet.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -1.08E+02 deg C   EXP
Boiling Point 65 deg C   EXP
pKa Dissociation Constant -2.08E+00 (none)   EXP
log P (octanol-water) 0.46 (none)   EXP
Water Solubility 1.00E+06 mg/L 20 EXP
Vapor Pressure 162 mm Hg 25 EXP
Henry's Law Constant 7.05E-05 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 1.61E-11 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.