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Substance Name: Ruxolitinib phosphate [USAN]
RN: 1092939-17-7
UNII: 436LRU32H5
InChIKey: JFMWPOCYMYGEDM-XFULWGLBSA-N

Note

  • NCI: The phosphate salt form of ruxolitinib, an orally bioavailable Janus-associated kinase (JAK) inhibitor with potential antineoplastic and immunomodulating activities. Ruxolitinib specifically binds to and inhibits protein tyrosine kinases JAK 1 and 2, which may lead to a reduction in inflammation and an inhibition of cellular proliferation. The JAK-STAT (signal transducer and activator of transcription) pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies. (NCI Thesaurus)

Molecular Formula

  • C17-H18-N6.H3-O4-P

Molecular Weight

  • 404.3649
 

Classification Codes

  • Antineoplastic Agents
  • Treatment of Cancer
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Names and Synonyms

Name of Substance

  • Ruxolitinib phosphate [USAN]

Synonyms

  • (3R)-3-Cyclopentyl-3-(4-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile phosphate (1:1)
  • INCB018424 salt
  • Jakafi
  • Jakavi
  • Ruxolitinib phosphate
  • UNII-436LRU32H5

Systematic Name

  • 1H-Pyrazole-1-propanenitrile, beta-cyclopentyl-4-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)-,(betaR)-, phosphate (1:1)

Registry Numbers

CAS Registry Number

  • 1092939-17-7

FDA UNII

  • 436LRU32H5

System Generated Number

  • 1092939177

Structure Descriptors

InChI

1S/C17H18N6.H3O4P/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16;1-5(2,3)4/h6,8-12,15H,1-5H2,(H,19,20,21);(H3,1,2,3,4)/t15-;/m1./s1

InChIKey

JFMWPOCYMYGEDM-XFULWGLBSA-N

Smiles

C(#N)C[C@H]([C@@H]1CCCC1)n1ncc(c1)c1ncnc2c1cc[nH]2.P(=O)(O)(O)O