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Substance Name: Vonicog alfa [USAN:INN]
RN: 109319-16-6


  • A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.

Classification Code

  • Prophylactic Treatment of Bleeding Episodes and Von Willebrand Disease
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Links to Resources

Names and Synonyms

Name of Substance

  • von Willebrand Factor
  • Vonicog alfa [USAN:INN]

MeSH Heading

  • von Willebrand Factor


  • BAX 111
  • Blood platelet-aggregating factor
  • F VIII-vWf
  • Factor VIII-Related Antigen
  • Factor VIIIR-Ag
  • Ristocetin cofactor
  • Ristocetin-Willebrand Factor
  • UNII-ZE22NE22F1
  • von Willebrand factor human
  • von Willebrand Protein
  • von Willebrand's factor
  • Vonicog alfa

Registry Numbers

CAS Registry Number

  • 109319-16-6


  • 5PKM8P0G5I
  • ZE22NE22F1

System Generated Number

  • 0109319166