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Substance Name: Pamidronate disodium [USAN:USP:JAN]
RN: 109552-15-0
UNII: 8742T8ZQZA
InChIKey: CZYWHNTUXNGDGR-UHFFFAOYSA-L

Classification Codes

  • Bone Resorption Inhibitor
  • Drug / Therapeutic Agent
  • Human Data

Molecular Formula

  • C3-H9-N-O7-P2.2Na.5H2-O

Molecular Weight

  • 369.1061
 
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Names and Synonyms

Name of Substance

  • Pamidronate disodium [USAN:USP:JAN]

Synonyms

  • Aredia
  • CGP 23339AE
  • Disodium (3-amino-1-hydroxypropylidene)bisphosphonate pentahydrate
  • Disodium dihydrogen (3-amino-1-hydroxypropylidene)diphosphonate, pentahydrate
  • Disodium pamidronate pentahydrate
  • Disodium-3-amino-1-hydroxypropylidene-1,1-diphosphonate pentahydrate
  • Pamidronate disodium
  • Pamidronate disodium pentahydrate
  • UNII-8742T8ZQZA

Systematic Name

  • Phosphonic acid, (3-amino-1-hydroxypropylidene)bis-, disodium salt, pentahydrate

Registry Numbers

CAS Registry Number

  • 109552-15-0

FDA UNII

  • 8742T8ZQZA

System Generated Number

  • 0109552150

Molecular Formulas

Molecular Formula

  • C3-H9-N-O7-P2.2Na.5H2-O

Molecular Formula Fragments

  • C3-H9-N-O7-P2
  • COMPONENT
  • H2-O
  • Na

Structure Descriptors

InChI

1S/C3H11NO7P2.2Na.5H2O/c4-2-1-3(5,12(6,7)8)13(9,10)11;;;;;;;/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11);;;5*1H2/q;2*+1;;;;;/p-2

InChIKey

CZYWHNTUXNGDGR-UHFFFAOYSA-L

Smiles

C(CN)C(O)(P(=O)(O)[O-])P(=O)(O)[O-].O.O.O.O.O.[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
women TDLo intravenous 1200ug/kg (1.2mg/kg) MUSCULOSKELETAL: OTHER CHANGES

BEHAVIORAL: ATAXIA
Australian and New Zealand Journal of Medicine. Vol. 27, Pg. 719, 1997.
women TDLo intravenous 1200ug/kg (1.2mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: EXCITEMENT
Australian and New Zealand Journal of Medicine. Vol. 27, Pg. 719, 1997.