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Substance Name: Neldazosin [INN]
RN: 109713-79-3
UNII: G3E7RO42MB
InChIKey: IOSMPEJNAQZKJT-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C18-H25-N5-O4

Molecular Weight

  • 375.4265
 
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Names and Synonyms

Name of Substance

  • Neldazosin [INN]

Synonyms

  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(3-hydroxy-1-oxobutyl)piperazine
  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(3-hydroxybutyryl)piperazine
  • HRO 2/145
  • Neldazosin
  • Neldazosina
  • Neldazosina [INN-Spanish]
  • Neldazosine
  • Neldazosine [INN-French]
  • Neldazosinum
  • Neldazosinum [INN-Latin]
  • UNII-G3E7RO42MB

Systematic Names

  • (+-)-1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(3-hydroxybutyryl)piperazine
  • Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(3-hydroxy-1-oxobutyl)-

Registry Numbers

CAS Registry Number

  • 109713-79-3

FDA UNII

  • G3E7RO42MB

System Generated Number

  • 0109713793

Structure Descriptors

InChI

1S/C18H25N5O4/c1-11(24)8-16(25)22-4-6-23(7-5-22)18-20-13-10-15(27-3)14(26-2)9-12(13)17(19)21-18/h9-11,24H,4-8H2,1-3H3,(H2,19,20,21)

InChIKey

IOSMPEJNAQZKJT-UHFFFAOYSA-N

Smiles

CC(CC(=O)N1CCN(CC1)c2nc3cc(c(cc3c(n2)N)OC)OC)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 198mg/kg (198mg/kg)   Drugs of the Future. Vol. 16, Pg. 512, 1991.
rat LD50 oral > 5gm/kg (5000mg/kg)   Drugs of the Future. Vol. 16, Pg. 512, 1991.