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Substance Name: Seneciphylline, hydrochloride
RN: 1098-44-8
InChIKey: WZVHKYDRAYKVHU-ZCPIKUEKSA-N

Classification Code

  • Natural Product

Molecular Formula

  • C18-H23-N-O5.Cl-H

Molecular Weight

  • 369.843
 
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Names and Synonyms

Synonyms

  • Jacodine hydrochloride
  • NCI-C61165
  • NSC 30622
  • Senecionan-11,16-dione, 13,19-didehydro-12-hydroxy-, hydrochloride
  • Seneciphyllin hydrochloride

Systematic Name

  • Seneciphylline, hydrochloride

Registry Numbers

CAS Registry Number

  • 1098-44-8

System Generated Number

  • 0001098448

Molecular Formulas

Molecular Formula

  • C18-H23-N-O5.Cl-H

Molecular Formula Fragments

  • C18-H23-N-O5
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H23NO5.ClH/c1-4-12-9-11(2)18(3,22)17(21)23-10-13-5-7-19-8-6-14(15(13)19)24-16(12)20;/h4-5,14-15,22H,2,6-10H2,1,3H3;1H/b12-4+;/t14-,15-,18-;/m1./s1

InChIKey

WZVHKYDRAYKVHU-ZCPIKUEKSA-N

Smiles

C1C(\C(O[C@H]2[C@@H]3[N@@](CC=C3COC([C@](C)(O)C1=C)=O)CC2)=O)=C\C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo intravenous 50mg/kg (50mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Pharmacology and Experimental Therapeutics. Vol. 68, Pg. 130, 1940.
mouse LDLo intravenous 50mg/kg (50mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: OTHER CHANGES
Journal of Pharmacology and Experimental Therapeutics. Vol. 68, Pg. 130, 1940.
rat LD50 intraperitoneal 77mg/kg (77mg/kg) BLOOD: HEMORRHAGE

VASCULAR: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Frontiers of Biology. Vol. 9, Pg. 142, 1968.
rat LDLo intravenous 60mg/kg (60mg/kg) CARDIAC: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Pharmacology and Experimental Therapeutics. Vol. 68, Pg. 130, 1940.
rat LDLo oral 25mg/kg (25mg/kg) BLOOD: HEMORRHAGE

GASTROINTESTINAL: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Nature. Vol. 179, Pg. 361, 1957.
rat LDLo unreported 77mg/kg (77mg/kg) LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL"

BLOOD: HEMORRHAGE
Pharmacological Reviews. Vol. 22, Pg. 429, 1970.