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Substance Name: Triflupromazine hydrochloride [USP:JAN]
RN: 1098-60-8
UNII: 9E75N4A5HM
InChIKey: FTNWXGFYRHWUKG-UHFFFAOYSA-N

Note

  • A phenothiazine used as an antipsychotic agent and as an antiemetic.

Molecular Formula

  • C18-H19-F3-N2-S.Cl-H

Molecular Weight

  • 388.883
 

Classification Codes

  • Antipsychotic
  • Drug / Therapeutic Agent
  • Mutation Data
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Names and Synonyms

Name of Substance

  • Triflupromazine hydrochloride
  • Triflupromazine hydrochloride [USP:JAN]

Synonyms

  • 10-(3-(Dimethylamino)propyl)-2-(trifluoromethyl)phenothiazine monohydrochloride
  • 10-(3-Dimethylaminopropyl)-2-(trifluoromethyl)phenothiazine hydrochloride
  • 10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-, monohydrochloride
  • EINECS 214-149-6
  • Flumazin
  • Fluopromazine monohydrochloride
  • Fluorofen
  • MC 4703
  • Neoprin
  • Nivoman
  • NSC 14959
  • NSC 17473
  • Psyquil
  • Siquil
  • Trifluopromazine hydrochloride
  • Trifluopromazine hydrochloride (VAN)
  • Triflupromazine HCl
  • Triflupromazine hydrochloride
  • Triflupromazine monohydrochloride
  • UNII-9E75N4A5HM
  • Vesprin
  • Vesprin hydrochloride

Systematic Names

  • 10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-, monohydrochloride
  • Phenothiazine, 10-(3-(dimethylamino)propyl)-2-(trifluoromethyl)-, monohydrochloride
  • Triflupromazine hydrochloride

Registry Numbers

CAS Registry Number

  • 1098-60-8

FDA UNII

  • 9E75N4A5HM

System Generated Number

  • 0001098608

Molecular Formulas

Molecular Formula

  • C18-H19-F3-N2-S.Cl-H

Molecular Formula Fragments

  • C18-H19-F3-N2-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H19F3N2S.ClH/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

InChIKey

FTNWXGFYRHWUKG-UHFFFAOYSA-N

Smiles

CN(C)CCCN1c2ccccc2Sc3c1cc(cc3)C(F)(F)F.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 17mg/kg (17mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION

BLOOD: HEMORRHAGE
Journal of Pharmacology and Experimental Therapeutics. Vol. 127, Pg. 55, 1959.
mouse LD50 intraperitoneal 102mg/kg (102mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Monographs on Therapy. Vol. 2, Pg. 214, 1957.
mouse LD50 intravenous 34mg/kg (34mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 56, 1972.
mouse LD50 oral 254mg/kg (254mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 56, 1972.
rat LDLo intraperitoneal 94mg/kg (94mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: FOOD INTAKE (ANIMAL)

BEHAVIORAL: ATAXIA
Monographs on Therapy. Vol. 2, Pg. 214, 1957.