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Substance Name: Amyl nitrite [USAN]
RN: 110-46-3
UNII: 5N0U5TUC9Z
InChIKey: OWFXIOWLTKNBAP-UHFFFAOYSA-N

Note

  • A vasodilator that is administered by inhalation. It is also used recreationally due to its supposed ability to induce euphoria and act as an aphrodisiac.

Molecular Formula

  • C5-H11-N-O2

Molecular Weight

  • 117.147
 

Classification Codes

  • Mutation Data
  • Vasodilator

Names and Synonyms

Name of Substance

  • Amyl nitrite [USAN]
  • Isoamyl nitrite

Synonyms

  • 3-Methylbutanol nitrite
  • 3-Methylbutyl nitrite
  • 4-01-00-01683 (Beilstein Handbook Reference)
  • AI3-25183
  • Amilnitrite
  • Amyl nitrite
  • Amyl nitrite (VAN)
  • Aspiral
  • BRN 0969510
  • CCRIS 1098
  • EINECS 203-770-8
  • HSDB 606
  • Isoamyl nitrite
  • Isopentyl nitrite
  • Nitramyl
  • Nitramyl (VAN)
  • Nitrous acid, 3-methylbutyl ester
  • Nitrous acid, isopentyl ester
  • NSC 7903
  • Pentanoli nitris
  • UNII-5N0U5TUC9Z
  • Vaporole

Systematic Names

  • Amyl nitrite, mixed isomers
  • Isoamyl nitrite
  • Isopentyl alcohol, nitrite
  • Nitrous acid, 3-methylbutyl ester

Registry Numbers

CAS Registry Number

  • 110-46-3

FDA UNII

  • 5N0U5TUC9Z

System Generated Number

  • 0000110463

Structure Descriptors

InChI

1S/C5H11NO2/c1-5(2)3-4-8-6-7/h5H,3-4H2,1-2H3

InChIKey

OWFXIOWLTKNBAP-UHFFFAOYSA-N

Smiles

C(CON=O)C(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo subcutaneous 250uL/kg (0.25mL/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
dog LDLo intravenous 167mg/kg (167mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Research Communications in Chemical Pathology and Pharmacology. Vol. 5, Pg. 889, 1973.
mouse LC50 inhalation 1430ppm/30M (1430ppm) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Neurobehavioral Toxicology and Teratology. Vol. 8, Pg. 139, 1986.
mouse LD50 intraperitoneal 130mg/kg (130mg/kg)   Research Communications in Chemical Pathology and Pharmacology. Vol. 5, Pg. 889, 1973.
mouse LD50 intravenous 51mg/kg (51mg/kg)   Research Communications in Chemical Pathology and Pharmacology. Vol. 5, Pg. 889, 1973.
mouse LD50 oral 852mg/kg (852mg/kg)   Weisheng Dulixue Zazhi. Journal of Health Toxicology. Vol. 5, Pg. 119, 1991.
rat LC50 inhalation 716ppm/4H (716ppm) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Fundamental and Applied Toxicology. Vol. 8, Pg. 101, 1987.
rat LD50 oral 505mg/kg (505mg/kg) BEHAVIORAL: GENERAL ANESTHETIC Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 41, Pg. 1583, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Boiling Point 99.2 deg C   EXP
log P (octanol-water) 2.770 (none)   EST
Atmospheric OH Rate Constant 4.47E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.