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Substance Name: Ethylene glycol monoethyl ether
RN: 110-80-5
UNII: IDK7C2HS09
InChIKey: ZNQVEEAIQZEUHB-UHFFFAOYSA-N

Note

  • Chemical remains on MTL because of additional testing actions (see OECD/SIDS listing)

Molecular Formula

  • C4-H10-O2

Molecular Weight

  • 90.121
 

Classification Codes

Classification Codes

  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • TSCA Flag S (Substance is Identified in a Proposed or Final SNUR (Significant New Use Rule) under TSCA)
  • Tumor Data

Superlist Classification Codes

  • Reportable Quantity (RQ) = 1000 lb
  • TWA (5 ppm); skin; BEI
  • TWA 200 ppm (740 mg/m3); skin

Names and Synonyms

Name of Substance

  • 2-Ethoxyethanol
  • Ethanol, 2-ethoxy-
  • Ethylene glycol monoethyl ether

Synonyms

  • 2-Ethoxyethanol
  • 2-Ethoxyethyl alcohol
  • AI3-01236
  • Athylenglykol-monoathylather
  • Athylenglykol-monoathylather [German]
  • beta-Ethoxyethanol
  • Bikanol E 1
  • CCRIS 2294
  • Cellosolve
  • Cellosolve solvent
  • Celosolv
  • Celosolv [Czech]
  • Dowanol 8
  • Dowanol EE
  • EC 203-804-1
  • EGEE
  • EINECS 203-804-1
  • Ektasolve EE
  • Emkanol
  • Eter monoetilico del etilenglicol
  • Eter monoetilico del etilenglicol [Spanish]
  • Ethanol, 2-ethoxy-
  • Ether monoethylique de l'ethylene-glycol
  • Ether monoethylique de l'ethylene-glycol [French]
  • Ethyl cellosolve
  • Ethyl ethylene glycol
  • Ethylene glycol ethyl ether
  • Ethylene glycol monoethyl ether
  • Ethylethylene glycol
  • Etoksyetylowy alkohol
  • Etoksyetylowy alkohol [Polish]
  • Glycol monoethyl ether
  • HSDB 54
  • Hydroxy ether
  • Jeffersol EE
  • NCI-C54853
  • NSC 8837
  • Oxitol
  • Plastiazan 60
  • Poly-Solv EE
  • RCRA waste number U227
  • RCRA waste number U359
  • Solvid
  • Solvulose
  • UNII-IDK7C2HS09

Systematic Names

  • 2-Ethoxyethanol
  • Ethanol, 2-ethoxy-

Superlist Names

  • 2-Ethoxyethanol
  • Cellosolve
  • EGEE
  • Ethanol, 2-ethoxy-
  • Ethoxyethanol, 2-
  • Ethylene glycol ethyl ether
  • Ethylene glycol monoethyl ether
  • Ethylene glycol monoethyl ether [UN1171] [Flammable liquid]
  • Glycol monoethyl ether
  • RCRA waste no. U359
  • UN1171

Registry Numbers

CAS Registry Number

  • 110-80-5

FDA UNII

  • IDK7C2HS09

Other Registry Number

  • 96231-36-6

System Generated Number

  • 0000110805

Structure Descriptors

InChI

1S/C4H10O2/c1-2-6-4-3-5/h5H,2-4H2,1H3

InChIKey

ZNQVEEAIQZEUHB-UHFFFAOYSA-N

Smiles

C(OCC)CO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LCLo inhalation 3000ppm/24H (3000ppm) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Public Health Reports. Vol. 45, Pg. 1459, 1930.
guinea pig LD50 oral 1400mg/kg (1400mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

GASTROINTESTINAL: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
guinea pig LD50 unreported 3070mg/kg (3070mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 47(5), Pg. 84, 1982.
mouse LC50 inhalation 1820ppm/7H (1820ppm) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ANALGESIA

KIDNEY, URETER, AND BLADDER: HEMATURIA
Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 157, 1943.
mouse LD50 intraperitoneal 1707mg/kg (1707mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

BLOOD: CHANGES IN SPLEEN

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 342, 1947.
mouse LD50 intravenous 3900mg/kg (3900mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 880, 1971.
mouse LD50 oral 2451mg/kg (2451mg/kg)   Kodak Company Reports. Vol. MSDS-10, Pg. 170A, 1982.
mouse LD50 unreported 5799mg/kg (5799mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 47(5), Pg. 84, 1982.
mouse LDLo subcutaneous 5gm/kg (5000mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 42, Pg. 355, 1931.
rabbit LD50 intravenous 900mg/kg (900mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 880, 1971.
rabbit LD50 oral 1275mg/kg (1275mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 53(10), Pg. 78, 1988.
rabbit LD50 skin 3300mg/kg (3300mg/kg)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 54, 1974.
rabbit LD50 subcutaneous 2gm/kg (2000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 880, 1971.
rat LC50 inhalation 2000ppm/7H (2000ppm)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 54, 1974.
rat LD50 intraperitoneal 2800mg/kg (2800mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 880, 1971.
rat LD50 intravenous 2400mg/kg (2400mg/kg)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 54, 1974.
rat LD50 oral 2125mg/kg (2125mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: WITHDRAWAL

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 32(3), Pg. 48, 1988.
rat LD50 skin 3900mg/kg (3900mg/kg)   Toxicologist. Vol. 4, Pg. 180, 1984.
rat LD50 subcutaneous 3400mg/kg (3400mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 880, 1971.
rat LD50 unreported 7750mg/kg (7750mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 47(5), Pg. 84, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -7.00E+01 deg C   EXP
Boiling Point 135 deg C   EXP
pKa Dissociation Constant 14.8 (none)   EXP
log P (octanol-water) -0.32 (none)   EXP
Water Solubility 1.00E+06 mg/L   EXP
Vapor Pressure 5.31 mm Hg 25 EXP
Henry's Law Constant 4.70E-07 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 1.54E-11 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.