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Substance Name: Piperazine [USP]
RN: 110-85-0
UNII: 1RTM4PAL0V
InChIKey: GLUUGHFHXGJENI-UHFFFAOYSA-N

Molecular Formula

  • C4-H10-N2

Molecular Weight

  • 86.137
 

Classification Codes

  • Agricultural Chemical
  • Anthelmintic
  • Anthelmintics
  • Anti-Infective Agents
  • Antinematodal Agents
  • Antiparasitic Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Skin / Eye Irritant
  • Unspecified / Unclassified Pesticide

Names and Synonyms

Name of Substance

  • Piperazine
  • Piperazine [USP]

Synonyms

  • 1,4-Diazacyclohexane
  • 1,4-Diethylenediamine
  • 1,4-Piperazine
  • 5-23-01-00030 (Beilstein Handbook Reference)
  • Antiren
  • Asca-Trol No. 3
  • BRN 0102555
  • CCRIS 5950
  • Diethylenediamine
  • Diethyleneimine
  • Dispermine
  • EC 203-808-3
  • EINECS 203-808-3
  • Entacyl
  • Eraverm
  • Eraverm (VAN)
  • Hexahydro-1,4-diazine
  • Hexahydropyrazine
  • HSDB 1093
  • Lumbrical
  • NSC 474
  • Piperazidine
  • Piperazin
  • Piperazin [German]
  • Piperazine
  • Piperazine, anhydrous
  • Pipersol
  • Pyrazine hexahydride
  • Pyrazine, hexahydro-
  • UNII-1RTM4PAL0V
  • Uvilon
  • Vermex
  • Worm-A-Ton
  • Wurmirazin

Systematic Name

  • Piperazine

Superlist Names

  • Piperazine
  • Piperazine [UN2579] [Corrosive]
  • UN2579

Registry Numbers

CAS Registry Number

  • 110-85-0

FDA UNII

  • 1RTM4PAL0V

Other Registry Numbers

  • 8017-90-1
  • 8027-81-4
  • 81546-15-8
  • 854880-15-2
  • 861800-35-3

Related Registry Numbers

  • 14007-05-7 (unspecified hydrobromide)
  • 142-63-2 (hexahydrate)
  • 142-64-3 (di-hydrochloride)
  • 14538-56-8 (phosphate[1:1])
  • 16832-43-2 (unspecified hydrate)
  • 1951-97-9 (unspecified phosphate)
  • 3597-26-0 (unspecified sulfate)
  • 6094-40-2 (unspecified hydrochloride)
  • 7542-23-6 (mono-hydrochloride)
  • 8057-14-5 (unspecified salt)

System Generated Number

  • 0000110850

Structure Descriptors

InChI

1S/C4H10N2/c1-2-6-4-3-5-1/h5-6H,1-4H2

InChIKey

GLUUGHFHXGJENI-UHFFFAOYSA-N

Smiles

C1CNCCN1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 75mg/kg (75mg/kg) BEHAVIORAL: SLEEP

GASTROINTESTINAL: NAUSEA OR VOMITING
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 478, 1969.
mouse LC50 inhalation 5400mg/m3/2H (5400mg/m3) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 15, Pg. 116, 1979.
mouse LD50 intraperitoneal 1900mg/kg (1900mg/kg)   Progress in Biochemical Pharmacology. Vol. 1, Pg. 542, 1965.
mouse LD50 intravenous 1180mg/kg (1180mg/kg)   Drugs in Japan Vol. 6, Pg. 635, 1982.
mouse LD50 oral 600mg/kg (600mg/kg)   Bollettino Chimico Farmaceutico. Vol. 103, Pg. 414, 1964.
rabbit LD50 skin 4mL/kg (4mL/kg)   Union Carbide Data Sheet. Vol. 7/16/1965,
rat LD50 intramuscular > 2500mg/kg (2500mg/kg)   Drugs in Japan Vol. 6, Pg. 635, 1982.
rat LD50 intravenous 1340mg/kg (1340mg/kg)   Drugs in Japan Vol. 6, Pg. 635, 1982.
rat LD50 oral 1900mg/kg (1900mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 15, Pg. 116, 1979.
rat LD50 subcutaneous 3700mg/kg (3700mg/kg)   Drugs in Japan Vol. 6, Pg. 635, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 106 deg C   EXP
Boiling Point 146 deg C   EXP
pKa Dissociation Constant 9.731 (none)   EXP
log P (octanol-water) -1.50E+00 (none)   EXP
Water Solubility 1.00E+06 mg/L 25 EXP
Vapor Pressure 0.16 mm Hg 20 EXP
Henry's Law Constant 2.20E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.69E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.