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Substance Name: Morpholine
RN: 110-91-8
UNII: 8B2ZCK305O
InChIKey: YNAVUWVOSKDBBP-UHFFFAOYSA-N

Molecular Formula

  • C4-H9-N-O

Molecular Weight

  • 87.1211
 

Classification Codes

Classification Codes

  • Mutation Data
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 3
  • TWA (20 ppm); skin; Not classifiable as a human carcinogen
  • TWA 20 ppm (70 mg/m3); skin

Names and Synonyms

Name of Substance

  • Morpholine
  • Tetrahydro-1,4-oxazine

Synonyms

  • 1-Oxa-4-azacyclohexane
  • 2H-1,4-Oxazine, tetrahydro-
  • 4-27-00-00015 (Beilstein Handbook Reference)
  • 4H-1,4-Oxazine, tetrahydro-
  • AI3-01231
  • BASF 238
  • BRN 0102549
  • Caswell No. 584
  • CCRIS 2482
  • Diethylene imidoxide
  • Diethylene oximide
  • Diethyleneimide oxide
  • Diethylenimide oxide
  • Drewamine
  • EC 203-815-1
  • EINECS 203-815-1
  • EPA Pesticide Chemical Code 054701
  • HSDB 102
  • Morpholine
  • NSC 9376
  • p-Isoxazine, tetrahydro-
  • Tetrahydro-1,4-isoxazine
  • Tetrahydro-1,4-oxazine
  • Tetrahydro-2H-1,4-oxazine
  • Tetrahydro-p-oxazine
  • UNII-8B2ZCK305O

Systematic Name

  • Morpholine

Superlist Names

  • Morpholine
  • Morpholine [UN2054] [Flammable liquid]
  • UN2054

Registry Numbers

CAS Registry Number

  • 110-91-8

FDA UNII

  • 8B2ZCK305O

Other Registry Numbers

  • 147366-31-2
  • 854893-20-2
  • 88542-81-8
  • 96122-95-1
  • 99108-56-2

Related Registry Numbers

  • 10024-89-2 (hydrochloride)
  • 34668-73-0 (phosphate[3:1])
  • 58464-45-2 (hydriodide)
  • 63079-67-4 (unspecified phosphate)
  • 76088-23-8 (sulfite[1:1])

System Generated Number

  • 0000110918

Structure Descriptors

InChI

1S/C4H9NO/c1-3-6-4-2-5-1/h5H,1-4H2

InChIKey

YNAVUWVOSKDBBP-UHFFFAOYSA-N

Smiles

C1COCCN1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo oral 100mg/kg (100mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION
Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 236, 1939.
mammal (species unspecified) LC50 inhalation 12000mg/m3 (12000mg/m3)   Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 90, 1975.
mammal (species unspecified) LD50 oral 1220mg/kg (1220mg/kg)   Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 14, Pg. 90, 1975.
mouse LC50 inhalation 1320mg/m3/2H (1320mg/m3) BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 8, Pg. 60, 1966.
mouse LD50 intraperitoneal 413mg/kg (413mg/kg)   Cancer Vol. 2, Pg. 1055, 1949.
mouse LD50 oral 525mg/kg (525mg/kg) BEHAVIORAL: SLEEP

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Biomedica Biochimica Acta. Vol. 44, Pg. 795, 1985.
mouse LD50 subcutaneous 458mg/kg (458mg/kg)   United States Patent Document. Vol. #4576951,
rabbit LD50 skin 500uL/kg (0.5mL/kg)   AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 10, Pg. 61, 1954.
rat LC50 inhalation 8000ppm/8H (8000ppm)   Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 85, 1974.
rat LD50 oral 1450mg/kg (1450mg/kg)   Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. Vol. 10, Pg. 25, 1968.
rat LDLo unreported 1600mg/kg (1600mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 662, 1969.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -4.90E+00 deg C   EXP
Boiling Point 128 deg C   EXP
pKa Dissociation Constant 8.492 (none) 25 EXP
log P (octanol-water) -0.86 (none)   EXP
Water Solubility 1.00E+06 mg/L   EXP
Vapor Pressure 10.1 mm Hg 25 EXP
Henry's Law Constant 1.16E-06 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.38E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.