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Substance Name: Strophanthin
RN: 11005-63-3
UNII: O6I3I9267L
InChIKey: OBAGDHZPZLEISV-TXZACQIRSA-N

Note

  • Induces arrhythmias.

Molecular Formula

  • C36-H54-O14

Molecular Weight

  • 736.89
 

Classification Codes

  • Cardiotonic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Natural Product
  • Protective Agents
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Names and Synonyms

Name of Substance

  • Strophanthin
  • Strophanthin K

Synonyms

  • Combetin
  • EINECS 234-239-9
  • Eustrophinum
  • k-Strophanthin
  • Kombe-strophanthin
  • Kombetin
  • Strophanthin
  • Strophantin
  • UNII-O6I3I9267L

Systematic Names

  • k-Strophanthin
  • Strophanthin

Registry Numbers

CAS Registry Number

  • 11005-63-3

FDA UNII

  • O6I3I9267L

Other Registry Numbers

  • 12671-69-1
  • 8001-51-2

System Generated Number

  • 0011005633

Structure Descriptors

InChI

1S/C39H60O13/c1-21-33(52-26-14-22(18-40)30(43)32(45)31(26)44)27(48-5)16-29(50-21)51-24-6-8-37(20-41)35(3)11-10-34(2)25(23-15-28(42)49-19-23)7-9-39(34,47)36(35,4)12-13-38(37,46)17-24/h15,20-22,24-27,29-33,40,43-47H,6-14,16-19H2,1-5H3/t21-,22+,24+,25-,26+,27-,29?,30+,31-,32-,33?,34-,35+,36-,37+,38+,39+/m1/s1

InChIKey

OBAGDHZPZLEISV-TXZACQIRSA-N

Smiles

C[C@@H]1C([C@@H](CC(O1)O[C@H]2CC[C@@]3([C@]4(CC[C@@]5([C@H](CC[C@]5([C@@]4(CC[C@@]3(C2)O)C)O)C6=CC(=O)OC6)C)C)C=O)OC)O[C@H]7C[C@H]([C@@H]([C@H]([C@@H]7O)O)O)CO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 110ug/kg (0.11mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 184, Pg. 181, 1937.
frog LD50 intravenous 690ug/kg (0.69mg/kg)   Compilation of LD50 Values of New Drugs.
frog LD50 oral 16500ug/kg (16.5mg/kg)   Japanese Journal of Pharmacology. Vol. 9, Pg. 91, 1960.
frog LD50 subcutaneous 440ug/kg (0.44mg/kg)   Japanese Journal of Pharmacology. Vol. 9, Pg. 91, 1960.
guinea pig LD50 intravenous 270ug/kg (0.27mg/kg)   Compilation of LD50 Values of New Drugs.
mammal (species unspecified) LD50 unreported 2450ug/kg (2.45mg/kg)   Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. Vol. 24(4), Pg. 42, 1990.
mammal (species unspecified) LDLo intravenous 222ug/kg (0.222mg/kg)   Acta Pharmaceutica Jugoslavica. Vol. 24, Pg. 179, 1974.
mouse LD50 intraperitoneal 2400ug/kg (2.4mg/kg)   Strahlentherapie. Vol. 127, Pg. 245, 1965.
mouse LD50 intravenous 1750ug/kg (1.75mg/kg)   Farmakologiya i Toksikologiya Vol. 38, Pg. 311, 1975.
mouse LD50 subcutaneous 2mg/kg (2mg/kg)   Farmakologiya i Toksikologiya Vol. 28, Pg. 46, 1965.
pigeon LDLo oral 40mg/kg (40mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
pigeon LDLo subcutaneous 600ug/kg (0.6mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
rabbit LDLo intravenous 200ug/kg (0.2mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 185, Pg. 329, 1937.
rabbit LDLo oral 20mg/kg (20mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
rabbit LDLo subcutaneous 250ug/kg (0.25mg/kg)   "Ueber die Wirkung Verschiedener Gifte Auf Vogel, Dissertation," Forchheimer, L., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1931Vol. -, Pg. -, 1931.
rat LD50 intravenous 7mg/kg (7mg/kg)   Archives of Toxicology. Vol. 54, Pg. 275, 1983.
rat LDLo subcutaneous 50mg/kg (50mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.