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Substance Name: Monazomycin
RN: 11006-31-8
InChIKey: BTUZNIQVZBANAX-XGVCMRGVSA-N

Note

  • Antibiotic produced by Streptomyces mashuensis; takacidn produced by S. griseoverticillatum; U-0412 produced by Streptoverticillium SP. KCC U-0142.

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C72-H133-N-O22

Molecular Weight

  • 1364.83
 
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Names and Synonyms

Name of Substance

  • Monazomycin

Synonyms

  • BRN 4648585
  • Takacidin
  • U 0142

Systematic Name

  • Monazomycin

Registry Numbers

CAS Registry Number

  • 11006-31-8

System Generated Number

  • 0011006318

Structure Descriptors

InChI

1S/C72H133NO22/c1-39-22-19-20-25-55(79)46(8)54(78)24-17-15-18-26-62(84)95-71(42(4)23-16-13-14-21-31-73)50(12)59(83)37-53(77)36-58(82)48(10)66(88)47(9)56(80)34-51(75)29-27-40(2)63(85)41(3)28-30-52(76)35-57(81)49(11)67(89)60(33-45(7)65(87)44(6)32-43(5)64(39)86)93-72-70(92)69(91)68(90)61(38-74)94-72/h19,22,28,30,32-33,39-42,44,46-61,63-72,74-83,85-92H,13-18,20-21,23-27,29,31,34-38,73H2,1-12H3/b22-19+,30-28-,43-32+,45-33+/t39?,40?,41?,42?,44?,46?,47?,48?,49?,50?,51?,52?,53?,54?,55?,56?,57?,58?,59?,60?,61-,63?,64?,65?,66?,67?,68-,69+,70+,71?,72+/m1/s1

InChIKey

BTUZNIQVZBANAX-XGVCMRGVSA-N

Smiles

O1C(CCCCC[C@@H]([C@@H]([C@@H](CCC=C[C@@H]([C@@H](C(=C[C@@H]([C@@H](C(=C[C@@H]([C@@H]([C@@H]([C@@H](C[C@@H](C=C[C@@H]([C@@H]([C@@H](CC[C@@H](C[C@@H]([C@@H]([C@@H]([C@@H]([C@@H](C[C@@H](C[C@@H]([C@@H]([C@@H]1[C@@H](CCCCCCN)C)C)O)O)O)C)O)C)O)O)C)O)C)O)O)C)O)O[C@@H]1[C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)C)O)C)C)O)C)O)C)O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 5mg/kg (5mg/kg)   "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 635, 1967.
mouse LD50 intravenous 5mg/kg (5mg/kg)   Journal of Antibiotics, Series A. Vol. 16, Pg. 127, 1963.
mouse LD50 oral 100mg/kg (100mg/kg)   "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967Vol. -, Pg. 635, 1967.