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Substance Name: Tirilazad [INN:BAN]
RN: 110101-66-1
UNII: YD064E883I
InChIKey: RBKASMJPSJDQKY-RBFSKHHSSA-N

Note

  • A lazaroid; potent inhibitor of iron-dependent lipid peroxidation; has shown excellent activity in in vivo models of experimental central nervous system trauma & ischemia; tradename Freedox.

Molecular Formula

  • C38-H52-N6-O2

Molecular Weight

  • 624.869
 

Classification Codes

  • Antioxidants
  • Central Nervous System Agents
  • Neuroprotective Agents
  • Protective Agents
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Names and Synonyms

Name of Substance

  • Tirilazad
  • Tirilazad [INN:BAN]

Synonyms

  • PNU 74006F
  • Tirilazad
  • Tirilazadum
  • Tirilazadum [INN-Latin]
  • U 74006
  • UNII-YD064E883I

Systematic Name

  • Pregna-1,4,9(11)-triene-3,20-dione, 21-(4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)erazinyl)-16-methyl-, (16alpha)-

Registry Numbers

CAS Registry Number

  • 110101-66-1

FDA UNII

  • YD064E883I

System Generated Number

  • 0110101661

Structure Descriptors

InChI

1S/C38H52N6O2/c1-26-22-31-29-9-8-27-23-28(45)10-12-37(27,2)30(29)11-13-38(31,3)35(26)32(46)25-41-18-20-43(21-19-41)34-24-33(42-14-4-5-15-42)39-36(40-34)44-16-6-7-17-44/h10-12,23-24,26,29,31,35H,4-9,13-22,25H2,1-3H3/t26-,29-,31+,35-,37+,38+/m1/s1

InChIKey

RBKASMJPSJDQKY-RBFSKHHSSA-N

Smiles

C1(C=C[C@@]2(C3=CC[C@@]4([C@H]([C@@H](C[C@@H]4[C@@H]3CCC2=C1)C)C(CN1CCN(CC1)c1nc(nc(c1)N1CCCC1)N1CCCC1)=O)C)C)=O