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Substance Name: Indoximod [USAN:INN]
RN: 110117-83-4
UNII: TX5CYN1KMZ
InChIKey: ZADWXFSZEAPBJS-SNVBAGLBSA-N

Note

  • NCI: A methylated tryptophan with anti-immunosuppressive activity. 1-methyl-d-tryptophan inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy. (NCI Thesaurus)

Molecular Weight

  • 218.2546
 
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Names and Synonyms

Name of Substance

  • D-Tryptophan, 1-methyl-
  • Indoximod [USAN:INN]

Synonyms

  • 1-Methyl-D-tryptophan
  • 1-MT
  • D-(+)-1-Methyltryptophan
  • D-1MT
  • D-l-Methyltryptophan
  • D-Tryptophan, 1-methyl-
  • Indoximod
  • NLG 8189
  • UNII-TX5CYN1KMZ

Systematic Name

  • D-Tryptophen, 1-methyl-

Registry Numbers

CAS Registry Number

  • 110117-83-4

FDA UNII

  • TX5CYN1KMZ

System Generated Number

  • 0110117834

Structure Descriptors

InChI

1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m1/s1

InChIKey

ZADWXFSZEAPBJS-SNVBAGLBSA-N

Smiles

Cn1cc(c2c1cccc2)C[C@H](C(=O)O)N