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Substance Name: Lodenosine [USAN:INN]
RN: 110143-10-7
UNII: 3WB2LGT4R1
InChIKey: KBEMFSMODRNJHE-JFWOZONXSA-N

Note

  • Anti-HIV nucleoside analog, the flourine atom on lodenosine is located at 2-arabinoside location, while 2'-fluoro-2',3'-dideoxyadenosine has the flourine residue at the 2-ribose sugar location.

Molecular Formula

  • C10-H12-F-N5-O2

Molecular Weight

  • 253.2358
 

Classification Code

  • Antiviral
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Names and Synonyms

Name of Substance

  • Lodenosine
  • Lodenosine [USAN:INN]

Synonyms

  • 2'-beta-Fluoro-2',3'-dideoxyadenosine
  • 2'-F-dd-ara-A
  • 2'-FddA
  • 9-(2,3-Dideoxy-2-fluoro-beta-D-threo-pentofuranosyl) adenine
  • 9-(2,3-Dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)-9H-purin-6-amine
  • CCRIS 9418
  • DRG-0246
  • F-ddA
  • Lodenosine
  • NSC 613792
  • UNII-3WB2LGT4R1

Systematic Name

  • 9H-Purin-6-amine, 9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl)-

Registry Numbers

CAS Registry Number

  • 110143-10-7

FDA UNII

  • 3WB2LGT4R1

System Generated Number

  • 0110143107

Structure Descriptors

InChI

1S/C10H12FN5O2/c11-6-1-5(2-17)18-10(6)16-4-15-7-8(12)13-3-14-9(7)16/h3-6,10,17H,1-2H2,(H2,12,13,14)/t5-,6-,10+/m0/s1

InChIKey

KBEMFSMODRNJHE-JFWOZONXSA-N

Smiles

c1nc(c2c(n1)n(cn2)[C@H]3[C@H](C[C@H](O3)CO)F)N

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -0.18 (none)   EXP
Water Solubility 1580 mg/L 25 EST
Vapor Pressure 4.20E-11 mm Hg 25 EST
Henry's Law Constant 1.66E-19 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.07E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.