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Substance Name: Properdin
RN: 11016-39-0


  • A 53-kDa protein that is a positive regulator of the alternate pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It stabilizes the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb) and protects it from rapid inactivation, thus facilitating the cascade of COMPLEMENT ACTIVATION and the formation of MEMBRANE ATTACK COMPLEX. Individuals with mutation in the PFC gene exhibit properdin deficiency and have a high susceptibility to infections.

Molecular Formula

  • Unspecified

Classification Code

  • Immunologic Factors
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Names and Synonyms

Name of Substance

  • Properdin

MeSH Heading

  • Properdin


  • Complement factor P

Systematic Name

  • Complement factor P

Registry Numbers

CAS Registry Number

  • 11016-39-0


  • A3IC79HJ0N

System Generated Number

  • 0011016390