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Substance Name: Sebriplatin [INN]
RN: 110172-45-7
UNII: GZ8I2X2FZK
InChIKey: IEFNEZUQHDYNRM-UHFFFAOYSA-L

Classification Codes

  • Antineoplastic Agents
  • Drug / Therapeutic Agent

Molecular Formula

  • C11-H20-N2-O4-Pt

Molecular Weight

  • 437.3532
 
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Names and Synonyms

Name of Substance

  • NK 121
  • Sebriplatin [INN]

Synonyms

  • (+)-cis-(1,1-Cyclobutanedicarboxylato)((2R)-2-methyl-1,4-butanediamine-N,N')platinum
  • (Z)-(Cyclobutane-1,1-dicarboxylato)((R)-2-methyl-1,4-butanediammine)platinum(II)
  • cis-1,1-Cyclobutanedicarboxylato-(2R)-2-methyl-1,4-butanediammineplatinum(II)
  • NK 121
  • Sebriplatin
  • UNII-GZ8I2X2FZK

Systematic Names

  • (+)-cis-(1,1-Cyclobutanedicarboxylato)((2R)-2-methyl-1,4-butanediamine-N,N')platinum
  • Platinum(II), (cyclobutane-1,1-dicarboxylato)((R)-2-methyl-1,4-butanediammine)-, (Z)-

Registry Numbers

CAS Registry Number

  • 110172-45-7

FDA UNII

  • GZ8I2X2FZK

System Generated Number

  • 0110172457

Structure Descriptors

InChI

1S/C6H8O4.C5H12N2.Pt/c7-4(8)6(5(9)10)2-1-3-6;1-5(4-7)2-3-6;/h1-3H2,(H,7,8)(H,9,10);5-7H,2-4H2,1H3;/q;-2;+4/p-2

InChIKey

IEFNEZUQHDYNRM-UHFFFAOYSA-L

Smiles

CC1CCN[Pt+2]2(NC1)[O-]C(=O)C3(CCC3)C(=O)[O-]2

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 14mg/kg (14mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Proceedings of the American Association for Cancer Research. Vol. 29, Pg. 339, 1988.
rat LDLo unreported 28mg/kg (28mg/kg)   Proceedings of the American Association for Cancer Research. Vol. 29, Pg. 339, 1988.