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Substance Name: Tylosin hydrochloride
RN: 11032-12-5
UNII: J606ECM5R3
InChIKey: OLLVTRJWJCUNEY-KWIMZRENSA-N

Note

  • Macrolide antibiotic obtained from cultures of Streptomyces fradiae. The drug is effective against many microorganisms in animals but not in humans.

Molecular Formula

  • C45-H77-N-O17.Cl-H

Molecular Weight

  • 952.565
 
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Names and Synonyms

Name of Substance

  • Tylosin hydrochloride

Synonym

  • UNII-J606ECM5R3

Systematic Name

  • Tylosin, hydrochloride

Registry Numbers

CAS Registry Number

  • 11032-12-5

FDA UNII

  • J606ECM5R3

Related Registry Number

  • 1401-69-0 (Parent)

System Generated Number

  • 0011032125

Molecular Formulas

Molecular Formula

  • C45-H77-N-O17.Cl-H

Molecular Formula Fragments

  • C45-H77-N-O17
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C46H77NO17.ClH/c1-13-33-30(22-58-45-42(57-12)41(56-11)37(52)26(5)60-45)18-23(2)14-15-31(49)24(3)19-29(16-17-48)39(25(4)32(50)20-34(51)62-33)64-44-38(53)36(47(9)10)40(27(6)61-44)63-35-21-46(8,55)43(54)28(7)59-35;/h14-15,17-18,24-30,32-33,35-45,50,52-55H,13,16,19-22H2,1-12H3;1H/b15-14+,23-18+;/t24-,25?,26-,27-,28+,29+,30?,32-,33-,35+,36-,37-,38-,39-,40-,41-,42-,43+,44+,45?,46-;/m1./s1

InChIKey

OLLVTRJWJCUNEY-KWIMZRENSA-N

Smiles

O([C@H]1[C@@H]([C@H]([C@H](O[C@H]2[C@H](C[C@H](C(C=CC(=C[C@@H]([C@H](OC(C[C@H]([C@@H]2C)O)=O)CC)CO[C@@H]2[C@@H]([C@@H]([C@H](O)[C@H](O2)C)OC)OC)C)=O)C)CC=O)O[C@@H]1C)O)N(C)C)[C@H]1C[C@@]([C@@H](O)[C@@H](O1)C)(C)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intravenous 4mg/kg (4mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Food and Cosmetics Toxicology. Vol. 4, Pg. 1, 1966.
mouse LD50 intravenous 582mg/kg (582mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Food and Cosmetics Toxicology. Vol. 4, Pg. 1, 1966.