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Substance Name: Josamycin HCl
RN: 11033-19-5
InChIKey: TYHGHVDZSRXAKD-XLSWTIJLSA-N

Note

  • A macrolide antibiotic from Streptomyces narbonensis. The drug has antimicrobial activity against a wide spectrum of pathogens.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C42-H69-N-O15.Cl-H

Molecular Weight

  • 864.46
 
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Names and Synonyms

Results Name

  • Josamycin HCl

Synonyms

  • Josamycin hydrochloride
  • Leucomycin A(sub 3) hydrochloride
  • Leucomycin A3 hydrochloride

Systematic Name

  • Leucomycin V, 3-acetate 4(sup B)-(3-methylbutanoate), hydrochloride

Registry Numbers

CAS Registry Number

  • 11033-19-5

System Generated Number

  • 0011033195

Molecular Formulas

Molecular Formula

  • C42-H69-N-O15.Cl-H

Molecular Formula Fragments

  • C42-H69-N-O15
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C42H69NO15.ClH/c1-23(2)19-32(47)56-40-27(6)53-34(22-42(40,8)50)57-37-26(5)54-41(36(49)35(37)43(9)10)58-38-29(17-18-44)20-24(3)30(46)16-14-12-13-15-25(4)52-33(48)21-31(39(38)51-11)55-28(7)45;/h12-14,16,18,23-27,29-31,34-41,46,49-50H,15,17,19-22H2,1-11H3;1H/b13-12+,16-14+;/t24-,25-,26-,27+,29+,30+,31-,34+,35-,36-,37-,38+,39+,40+,41+,42-;/m1./s1

InChIKey

TYHGHVDZSRXAKD-XLSWTIJLSA-N

Smiles

C[C@@H]1C/C=C/C=C/[C@@H]([C@@H](C[C@@H]([C@@H]([C@H]([C@@H](CC(=O)O1)OC(=O)C)OC)O[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)C)O[C@H]3C[C@@]([C@H]([C@@H](O3)C)OC(=O)CC(C)C)(C)O)N(C)C)O)CC=O)C)O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 520mg/kg (520mg/kg)   Journal of Antibiotics, Series A. Vol. 20, Pg. 181, 1967.
mouse LD50 intravenous 188mg/kg (188mg/kg)   Chemotherapy Vol. 17, Pg. 576, 1969.
mouse LD50 subcutaneous 786mg/kg (786mg/kg)   Chemotherapy Vol. 17, Pg. 576, 1969.