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Substance Name: Coformycin
RN: 11033-22-0
UNII: E49510ZL0H
InChIKey: YOOVTUPUBVHMPG-LODYRLCVSA-N

Note

  • A ribonucleoside antibiotic synergist and adenosine deaminase inhibitor isolated from Nocardia interforma and Streptomyces kaniharaensis. It is proposed as an antineoplastic synergist and immunosuppressant.

Molecular Formula

  • C11-H16-N4-O5

Molecular Weight

  • 284.27
 

Classification Codes

  • Antibiotics, Antineoplastic
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Immunologic Factors
  • Immunosuppressive Agents
  • Natural Product
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Names and Synonyms

Name of Substance

  • Coformycin

MeSH Heading

  • Coformycin

Synonyms

  • (R)-3,4,7,8-Tetrahydro-3-beta-D-ribofuranosylimidazo(4,5-d)(1,3)diazepin-8-ol
  • Coformycin
  • NSC 277817
  • UNII-E49510ZL0H

Systematic Name

  • Imidazo(4,5-d)(1,3)diazepin-8-ol, 3,4,7,8-tetrahydro-3-beta-D-ribofuranosyl-, (R)-

Registry Numbers

CAS Registry Number

  • 11033-22-0

FDA UNII

  • E49510ZL0H

System Generated Number

  • 0011033220

Structure Descriptors

InChI

1S/C11H16N4O5/c16-2-6-8(18)9(19)11(20-6)15-4-14-7-5(17)1-12-3-13-10(7)15/h3-6,8-9,11,16-19H,1-2H2,(H,12,13)/t5-,6-,8-,9-,11-/m1/s1

InChIKey

YOOVTUPUBVHMPG-LODYRLCVSA-N

Smiles

n1(c2c([C@@H](CNC=N2)O)nc1)[C@@H]1O[C@H](CO)[C@H]([C@H]1O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 35mg/kg (35mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 5, Pg. 330, 1981.