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Substance Name: Meclizine dihydrochloride
RN: 1104-22-9
UNII: L997QXC9J1
InChIKey: VCTHNOIYJIXQLV-UHFFFAOYSA-N

Note

  • A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.

Molecular Formula

  • C25-H27-Cl-N2.2Cl-H

Molecular Weight

  • 463.8771
 

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect
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Names and Synonyms

Results Name

  • Meclizine dihydrochloride

Name of Substance

  • Meclizine hydrochloride anhydrous

MeSH Heading

  • Meclizine

Synonyms

  • 1-p-Chlorbenzhydryl-m-methylbenzylpiperazine dihydrochloride
  • Ancolan dihydrochloride
  • Bonamine
  • Diadril
  • Duremesin
  • EINECS 214-164-8
  • Meclizine dihydrochloride
  • Meclizine HCl
  • Meclozine dihydrochloride
  • Navidoxine
  • NSC 28728
  • Parachloramine dihydrochloride
  • Postafen
  • Postafene dihydrochloride
  • Taizer
  • UNII-L997QXC9J1
  • V-Cline
  • Vertizine

Systematic Names

  • Meclozine dihydrochloride
  • Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-, dihydrochloride
  • Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((3-methylphenyl)methyl)-, hydrochloride (1:2)
  • Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-(m-methylbenzyl)-, dihydrochloride

Mixture Name

  • Antivert

Registry Numbers

CAS Registry Number

  • 1104-22-9

FDA UNII

  • L997QXC9J1

Other Registry Number

  • 1639-65-2

Related Registry Number

  • 569-65-3 (Parent)

System Generated Number

  • 0001104229

Molecular Formulas

Molecular Formula

  • C25-H27-Cl-N2.2Cl-H

Molecular Formula Fragments

  • C25-H27-Cl-N2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C25H27ClN2.2ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;/h2-13,18,25H,14-17,19H2,1H3;2*1H

InChIKey

VCTHNOIYJIXQLV-UHFFFAOYSA-N

Smiles

Cc1cccc(c1)CN2CCN(CC2)C(c3ccccc3)c4ccc(cc4)Cl.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 625mg/kg (625mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY OBSTRUCTION

BEHAVIORAL: EXCITEMENT
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 43, Pg. 653, 1954.
mouse LD50 oral 1600mg/kg (1600mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 67, 1969.