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Substance Name: Dolastatin 10
RN: 110417-88-4
UNII: EI946JT51X
InChIKey: OFDNQWIFNXBECV-VFSYNPLYSA-N

Note

  • From mollusk Dolabella auricularia; contains four amino acids, dolavaline, dolaisoleucine, dolaproine, valine and the primary amine dolaphenine.

Molecular Formula

  • C42-H68-N6-O6-S

Molecular Weight

  • 785.1012
 

Classification Codes

  • Antimitotic Agents
  • Antineoplastic Agents
  • Mitosis Modulators
  • Tubulin Modulators
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Names and Synonyms

Name of Substance

  • Dolastatin 10

Synonyms

  • CCRIS 7310
  • Dolastatin-10
  • NSC 376128
  • UNII-EI946JT51X

Systematic Names

  • Dolastatin 10
  • L-Valinamide, N,N-dimethyl-L-valyl-N-(2-methoxy-4-(2-(1-methoxy-2-methyl-3-oxo-3-((2-phenyl-1-(2-thiazolyl)ethyl)amino)propyl)-1-pyrrolidinyl)-1-(1-methylpropyl)-4-oxobutyl)-N-methyl-, (2S-(1(1R*(R*),2S*),2R*(1S*,2S*,3(R*))))-

Registry Numbers

CAS Registry Number

  • 110417-88-4

FDA UNII

  • EI946JT51X

System Generated Number

  • 0110417884

Structure Descriptors

InChI

1S/C42H68N6O6S/c1-13-28(6)37(47(10)42(52)35(26(2)3)45-40(51)36(27(4)5)46(8)9)33(53-11)25-34(49)48-22-17-20-32(48)38(54-12)29(7)39(50)44-31(41-43-21-23-55-41)24-30-18-15-14-16-19-30/h14-16,18-19,21,23,26-29,31-33,35-38H,13,17,20,22,24-25H2,1-12H3,(H,44,50)(H,45,51)/t28-,29+,31-,32-,33+,35-,36-,37-,38+/m0/s1

InChIKey

OFDNQWIFNXBECV-VFSYNPLYSA-N

Smiles

CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc2ccccc2)c3nccs3)OC)N(C)C(=O)[C@@H](NC(=O)[C@H](C(C)C)N(C)C)C(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 45ug/kg (0.045mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Cancer Chemotherapy and Pharmacology. Vol. 44, Pg. 395, 1999.
mouse LDLo intravenous 675ug/kg (0.675mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BLOOD: CHANGES IN LEUCOCYTE (WBC) COUNT
Cancer Chemotherapy and Pharmacology. Vol. 44, Pg. 395, 1999.
rat LDLo intravenous 100ug/kg (0.1mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Cancer Chemotherapy and Pharmacology. Vol. 44, Pg. 395, 1999.