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Substance Name: Gamma oryzanol [JAN]
RN: 11042-64-1
UNII: SST9XCL51M
InChIKey: FODTZLFLDFKIQH-FSVGXZBPSA-N

Note

  • Present in rice bran is associated with various physiological functions.

Molecular Formula

  • C40-H58-O4

Molecular Weight

  • 602.8942
 

Classification Codes

  • Anti-Ulcer Agents
  • Antilipemic Agents
  • Antimetabolites
  • Gastrointestinal Agents
  • Hypolipidemic Agents
  • Lipid Regulating Agents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Gamma oryzanol [JAN]
  • gamma-Orizanol
  • Oryzanol

Synonyms

  • CCRIS 4251
  • Gamma oryzanol
  • gamma-Orizanol
  • Gammariza
  • HI-Z
  • Oliver
  • OZ
  • UNII-SST9XCL51M

Systematic Names

  • 9,19-Cyclo-9beta-lanost-24-en-3beta-ol 4-hydroxy-3-methoxycinamate
  • gamma-Oryzanol

Registry Numbers

CAS Registry Number

  • 11042-64-1

FDA UNII

  • SST9XCL51M

System Generated Number

  • 0011042641

Structure Descriptors

InChI

1S/C40H58O4/c1-26(2)10-9-11-27(3)29-18-20-38(7)33-16-15-32-36(4,5)34(19-21-39(32)25-40(33,39)23-22-37(29,38)6)44-35(42)17-13-28-12-14-30(41)31(24-28)43-8/h10,12-14,17,24,27,29,32-34,41H,9,11,15-16,18-23,25H2,1-8H3/b17-13+/t27-,29-,32+,33+,34+,37-,38+,39-,40+/m1/s1

InChIKey

FODTZLFLDFKIQH-FSVGXZBPSA-N

Smiles

C[C@H](CCC=C(C)C)[C@H]1CC[C@@]2([C@@]1(CC[C@]34[C@H]2CC[C@@H]5[C@]3(C4)CC[C@@H](C5(C)C)OC(=O)/C=C/c6ccc(c(c6)OC)O)C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 5gm/kg (5000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 2401, 1978.
guinea pig LD50 skin 100mg/kg (100mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 7, Pg. 1295, 1979.
mouse LD intramuscular > 500mg/kg (500mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2781, 1973.
mouse LD intraperitoneal > 10gm/kg (10000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2781, 1973.
mouse LD subcutaneous > 2500mg/kg (2500mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2781, 1973.
mouse LD50 intravenous 811mg/kg (811mg/kg)   Drugs in Japan Vol. -, Pg. 297, 1995.
mouse LD50 oral > 25gm/kg (25000mg/kg)   Drugs in Japan Vol. -, Pg. 297, 1995.
rabbit LD oral > 5gm/kg (5000mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 2401, 1978.
rabbit LD subcutaneous > 2500mg/kg (2500mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 6, Pg. 2401, 1978.
rat LD intramuscular > 500mg/kg (500mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2781, 1973.
rat LD subcutaneous > 1gm/kg (1000mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2781, 1973.
rat LD50 intravenous 382mg/kg (382mg/kg)   Drugs in Japan Vol. -, Pg. 297, 1995.
rat LD50 oral > 25gm/kg (25000mg/kg)   Drugs in Japan Vol. -, Pg. 297, 1995.
rat LD50 skin 100mg/kg (100mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 7, Pg. 1295, 1979.
rat LDLo intraperitoneal 1250mg/kg (1250mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 7, Pg. 2781, 1973.