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Substance Name: Lasalocid
RN: 11054-70-9
InChIKey: BBMULGJBVDDDNI-UHFFFAOYSA-N

Note

  • Cationic ionophore antibiotic obtained from Streptomyces lasaliensis that, among other effects, dissociates the calcium fluxes in muscle fibers. It is used as a coccidiostat, especially in poultry.

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product
  • Skin / Eye Irritant

Molecular Formula

  • Unspecified

Molecular Weight

  • 590.793
 
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Names and Synonyms

Synonyms

  • Antibiotic X 537
  • Bovatec R
  • Lasalocid

Systematic Name

  • Lasalocid

Registry Numbers

CAS Registry Number

  • 11054-70-9

System Generated Number

  • 0011054709

Structure Descriptors

InChI

1S/C34H54O8/c1-9-25(31-21(6)18-34(11-3,42-31)26-16-17-33(40,10-2)23(8)41-26)30(37)22(7)28(35)19(4)12-14-24-15-13-20(5)29(36)27(24)32(38)39/h13,15,19,21-23,25-26,28,31,35-36,40H,9-12,14,16-18H2,1-8H3,(H,38,39)

InChIKey

BBMULGJBVDDDNI-UHFFFAOYSA-N

Smiles

O1[C@@]([C@@H]2O[C@@H]([C@@](CC)(O)CC2)C)(C[C@@H](C)[C@@H]1[C@@H](C([C@@H]([C@@H]([C@@H](CCc1c(c(c(C)cc1)O)C(O)=O)C)O)C)=O)CC)CC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
horse/donkey LD50 oral 22mg/kg (22mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: ATAXIA
American Journal of Veterinary Research. Vol. 42, Pg. 456, 1981.
rat LD50 intraperitoneal 8mg/kg (8mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Drug and Chemical Toxicology. Vol. 8, Pg. 451, 1985.