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Substance Name: Bleomycin [INN:BAN]
RN: 11056-06-7
UNII: 40S1VHN69B
InChIKey: OYVAGSVQBOHSSS-WXFSZRTFSA-O
Note
- A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
Molecular Formula
- C55-H84-N20-O21-S2.C55-H84-N17-O21-S3
Molecular Weight
- 1415.5646
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
Classification Codes
- Antibiotics, Antineoplastic
- Antineoplastic Agents
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Reproductive Effect
- Skin / Eye Irritant
- Tumor Data
Superlist Classification Code
- Overall Carcinogenic Evaluation: Group 2B
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Other Resources (Internet Locators)
Search for this InChIKey on the Web
Names and Synonyms
Results Name
- Bleomycin [INN:BAN]
Name of Substance
- Bleomycin
- Bleomycin [INN:BAN]
- Bleomycin [INN]
MeSH Heading
- Bleomycin
Synonyms
- Bleocin
- Bleomicin
- Bleomicina
- Bleomicina [INN-Spanish]
- Bleomycin
- Bleomycine
- Bleomycine [INN-French]
- Bleomycinum
- Bleomycinum [INN-Latin]
- CCRIS 2754
- HSDB 3208
- NDC 0015-3010
- NSC 125066
- UNII-40S1VHN69B
Systematic Name
- Bleomycin
Superlist Name
- Bleomycins
Registry Numbers
CAS Registry Number
- 11056-06-7
FDA UNII
- 40S1VHN69B
Other Registry Numbers
- 1400-95-9
- 37208-04-1
- 37293-16-6
- 37353-43-8
Related Registry Number
- 9041-93-4 (sulfate (salt))
System Generated Number
- 0011056067
Molecular Formulas
Molecular Formula
- C55-H84-N20-O21-S2.C55-H84-N17-O21-S3
Molecular Formula Fragments
- C55-H84-N17-O21-S3
- C55-H84-N20-O21-S2
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C55H83N17O21S3/c1-20-33(69-46(72-44(20)58)25(12-31(57)76)64-13-24(56)45(59)82)50(86)71-35(41(26-14-61-19-65-26)91-54-43(39(80)37(78)29(15-73)90-54)92-53-40(81)42(93-55(60)88)38(79)30(16-74)89-53)51(87)66-22(3)36(77)21(2)47(83)70-34(23(4)75)49(85)63-10-8-32-67-28(18-94-32)52-68-27(17-95-52)48(84)62-9-7-11-96(5)6/h14,17-19,21-25,29-30,34-43,53-54,64,73-75,77-81H,7-13,15-16,56H2,1-6H3,(H13-,57,58,59,60,61,62,63,65,66,69,70,71,72,76,82,83,84,85,86,87,88)/p+1/t21-,22+,23+,24-,25-,29?,30?,34-,35-,36-,37?,38?,39?,40?,41-,42?,43?,53?,54?/m0/s1InChIKey
OYVAGSVQBOHSSS-WXFSZRTFSA-OSmiles
C[C@@H](O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD | oral | > 100mg/kg (100mg/kg) | Japanese Journal of Antibiotics. Vol. 28, Pg. 1, 1975. | |
human | LDLo | intramuscular | 418mg/kg (418mg/kg) | LUNGS, THORAX, OR RESPIRATION: FIBROSING ALVEOLITIS LUNGS, THORAX, OR RESPIRATION: DYSPNEA | American Journal of Clinical Pathology. Vol. 58, Pg. 501, 1972. |
human | LDLo | intravenous | 351mg/kg (351mg/kg) | LUNGS, THORAX, OR RESPIRATION: FIBROSING ALVEOLITIS LUNGS, THORAX, OR RESPIRATION: DYSPNEA | American Journal of Clinical Pathology. Vol. 58, Pg. 501, 1972. |
mouse | LD50 | intramuscular | 270mg/kg (270mg/kg) | Pharmaceutical Chemistry Journal Vol. 17, Pg. 785, 1983. | |
mouse | LD50 | intraperitoneal | 35mg/kg (35mg/kg) | Journal of Antibiotics. Vol. 37, Pg. 239, 1984. | |
mouse | LD50 | intraperitoneal | 35mg/kg (35mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: ATAXIA | Antibiotics Annual. Vol. 2, Pg. 806, 1954/1955. |
mouse | LD50 | intravenous | 53mg/kg (53mg/kg) | Journal of Antibiotics. Vol. 31, Pg. 667, 1978. | |
mouse | LD50 | oral | > 2gm/kg (2000mg/kg) | Japanese Journal of Antibiotics. Vol. 28, Pg. 1, 1975. | |
mouse | LD50 | subcutaneous | 188mg/kg (188mg/kg) | Yakkyoku. Pharmacy. Vol. 25, Pg. 573, 1974. | |
mouse | LDLo | intratracheal | 14mg/kg (14mg/kg) | Toxicology Letters. Vol. 30, Pg. 63, 1986. | |
rat | LD | oral | > 200mg/kg (200mg/kg) | Japanese Journal of Antibiotics. Vol. 28, Pg. 1, 1975. | |
rat | LD50 | intraperitoneal | 168mg/kg (168mg/kg) | "Bleomycin: Current Status and New Development, Papers Presented in a Symposium, Oakland, CA, 1977," Carter, S.K., et al., eds., New York, Academic Press, Inc., 1978Vol. -, Pg. 311, 1978. | |
rat | LD50 | subcutaneous | 168mg/kg (168mg/kg) | Yakkyoku. Pharmacy. Vol. 25, Pg. 573, 1974. | |
rat | LDLo | intratracheal | 4units/kg (4units/kg) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: FIBROSIS (INTERSTITIAL) LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI | Lung. Vol. 161, Pg. 287, 1983. |