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Substance Name: Insulin human [USAN:USP:INN:BAN]
RN: 11061-68-0
UNII: 1Y17CTI5SR
InChIKey: PBGKTOXHQIOBKM-FHFVDXKLSA-N

Notes

  • A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
  • A protein that has the normal structure of the natural antidiabetic principle produced by the human pancreas. Insulin (human).

Molecular Formula

  • C257-H383-N65-O77-S6

Molecular Weight

  • 5807.6267
 

Classification Codes

  • Antidiabetic
  • Drug / Therapeutic Agent
  • Hypoglycemic Agents

Names and Synonyms

Name of Substance

  • Insulin human [USAN:USP:INN:BAN]

MeSH Heading

  • Insulin

Synonyms

  • Actrapid
  • Actrapid HM
  • Afrezza
  • Biohulin
  • EINECS 234-279-7
  • H-Tronin
  • Human insulin
  • Human Protaphane
  • Humulin
  • Humulin 70/30
  • Humulin N
  • Humulin N-U 100
  • Humulin R
  • Humulin S
  • Humuline
  • IN 105
  • Incelligent AF
  • Incelligent SG
  • Insugen
  • Insulin
  • Insulin (Cercopithecus aethiops)
  • Insulin (human)
  • Insulin (Macaca fascicularis)
  • Insulin (Macaca mulatta)
  • Insulin (Pan troglodytes)
  • Insulin human
  • Insulin human (biosynthesis)
  • Insulin U-500
  • Insulin, human synthetic
  • Insulina humana
  • Insulina humana [Spanish]
  • Insuline humaine
  • Insuline humaine [French]
  • Insulinum humanum
  • Insulinum humanum [Latin]
  • Insuman Rapid
  • Isuhuman
  • Jusuline
  • L-Threonine, L-phenylalanyl-L-valyl-L-asparaginyl-L-glutaminyl-L-histidyl-L-leucyl-L-cysteinylglycyl-L-seryl-L-histidyl-L-leucyl-L-valyl-L-alpha-glutamyl-L-alanyl-L-leucyl-L-tyrosyl-L-leucyl-L-valyl-L-cysteinylglycyl-L-alpha-glutamyl-L-arginylglycyl-L-phenylalanyl-L-phenylalanyl-L-tyrosyl-L-threonyl-L-prolyl-L-lysyl-, cyclic (7-7'),(19-20')-bis(disulfide) with glycyl-L-isoleucyl-L-valyl-L-alpha-glutamyl-L-glutaminyl-L-cysteinyl-L-cysteinyl-L-threonyl-L-seryl-L-isoleucyl-L-cysteinyl-L-seryl-L-leucyl-L-tyrosyl-L-glutaminyl-L-leucyl-L-alpha-glutamyl-L-asparaginyl-L_tyrosyl-L-cysteinyl-L-asparagine cyclic (6'-11')-disulfide
  • NN 1953
  • Novolin
  • Novolin R
  • Oral-lyn
  • ORMD 0801
  • Penfil R
  • Regular human insulin
  • Ultraphane
  • Umulin
  • Umulin Rapide
  • UNII-1Y17CTI5SR
  • Velosulin
  • Velosulin HM
  • Velosuline HM
  • Viaject

Systematic Names

  • A protein that has the normal structure of the natural antidiabetic principle produced by the human pancreas
  • Insulin (human)
  • Insulin (ox), 8A-L-threonine-10A-L-isoleucine-30B-L-threonine-
  • Insulin human (synthesis)

Registry Numbers

CAS Registry Number

  • 11061-68-0

FDA UNII

  • 1Y17CTI5SR

Other Registry Numbers

  • 1021924-27-5
  • 1038820-20-0
  • 1104460-98-1
  • 1146625-72-0
  • 1171191-96-0
  • 1171210-94-8
  • 1171228-96-8
  • 1171244-30-6
  • 1245604-13-0

System Generated Number

  • 0011061680

Structure Descriptors

InChI

1S/C257H383N65O77S6/c1-29-131(23)205(313-193(339)104-259)252(393)317-204(130(21)22)248(389)288-159(75-82-200(349)350)217(358)282-156(71-78-189(263)335)221(362)308-183-116-403-404-117-184-243(384)305-178(111-324)240(381)294-162(88-123(7)8)225(366)295-168(95-140-53-61-146(329)62-54-140)228(369)283-154(69-76-187(261)333)218(359)290-161(87-122(5)6)223(364)285-158(74-81-199(347)348)220(361)302-174(101-190(264)336)235(376)298-170(97-142-57-65-148(331)66-58-142)231(372)309-182(242(383)304-176(255(396)397)103-192(266)338)115-402-401-114-181(214(355)273-107-194(340)278-153(72-79-197(343)344)216(357)281-151(51-42-84-271-257(267)268)212(353)272-108-195(341)279-166(93-138-46-36-32-37-47-138)227(368)297-167(94-139-48-38-33-39-49-139)230(371)299-171(98-143-59-67-149(332)68-60-143)238(379)320-208(135(27)327)254(395)322-85-43-52-186(322)246(387)286-152(50-40-41-83-258)222(363)321-209(136(28)328)256(398)399)311-250(391)203(129(19)20)316-236(377)164(90-125(11)12)292-229(370)169(96-141-55-63-147(330)64-56-141)296-224(365)160(86-121(3)4)289-210(351)133(25)277-215(356)157(73-80-198(345)346)287-247(388)202(128(17)18)315-237(378)165(91-126(13)14)293-233(374)173(100-145-106-270-120-276-145)301-239(380)177(110-323)280-196(342)109-274-213(354)180(113-400-405-118-185(310-244(183)385)245(386)319-207(134(26)326)253(394)306-179(112-325)241(382)318-206(132(24)30-2)251(392)312-184)307-226(367)163(89-124(9)10)291-232(373)172(99-144-105-269-119-275-144)300-219(360)155(70-77-188(262)334)284-234(375)175(102-191(265)337)303-249(390)201(127(15)16)314-211(352)150(260)92-137-44-34-31-35-45-137/h31-39,44-49,53-68,105-106,119-136,150-186,201-209,323-332H,29-30,40-43,50-52,69-104,107-118,258-260H2,1-28H3,(H2,261,333)(H2,262,334)(H2,263,335)(H2,264,336)(H2,265,337)(H2,266,338)(H,269,275)(H,270,276)(H,272,353)(H,273,355)(H,274,354)(H,277,356)(H,278,340)(H,279,341)(H,280,342)(H,281,357)(H,282,358)(H,283,369)(H,284,375)(H,285,364)(H,286,387)(H,287,388)(H,288,389)(H,289,351)(H,290,359)(H,291,373)(H,292,370)(H,293,374)(H,294,381)(H,295,366)(H,296,365)(H,297,368)(H,298,376)(H,299,371)(H,300,360)(H,301,380)(H,302,361)(H,303,390)(H,304,383)(H,305,384)(H,306,394)(H,307,367)(H,308,362)(H,309,372)(H,310,385)(H,311,391)(H,312,392)(H,313,339)(H,314,352)(H,315,378)(H,316,377)(H,317,393)(H,318,382)(H,319,386)(H,320,379)(H,321,363)(H,343,344)(H,345,346)(H,347,348)(H,349,350)(H,396,397)(H,398,399)(H4,267,268,271)/t131-,132-,133-,134+,135+,136+,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,178-,179-,180-,181-,182-,183-,184-,185-,186-,201-,202-,203-,204-,205-,206-,207-,208-,209-/m0/s1

InChIKey

PBGKTOXHQIOBKM-FHFVDXKLSA-N

Smiles

CC[C@H](C)[C@H](NC(=O)CN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc3c[nH]cn3)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC(=O)N)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc4ccccc4)C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc5c[nH]cn5)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc6ccc(O)cc6)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](Cc7ccc(O)cc7)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](Cc8ccc(O)cc8)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC2=O)C(=O)N[C@@H](CC(=O)N)C(=O)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](Cc9ccccc9)C(=O)N[C@@H](Cc%10ccccc%10)C(=O)N[C@@H](Cc%11ccc(O)cc%11)C(=O)N[C@@H]([C@@H](C)O)C(=O)N%12CCC[C@H]%12C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)NC1=O)[C@@H](C)O)[C@@H](C)CC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 3937units/kg (3937units/kg)   Yakkyoku. Pharmacy. Vol. 37, Pg. 1633, 1986.
mouse LD50 intravenous > 4ku/kg (4000iu/kg)   Yakkyoku. Pharmacy. Vol. 37, Pg. 1633, 1986.
mouse LD50 subcutaneous > 4ku/kg (4000iu/kg)   Yakkyoku. Pharmacy. Vol. 37, Pg. 1633, 1986.
rat LD50 intraperitoneal > 4ku/kg (4000iu/kg)   Yakkyoku. Pharmacy. Vol. 37, Pg. 1633, 1986.
rat LD50 intravenous > 4ku/kg (4000iu/kg)   Yakkyoku. Pharmacy. Vol. 37, Pg. 1633, 1986.
rat LD50 subcutaneous > 4ku/kg (4000iu/kg)   Yakkyoku. Pharmacy. Vol. 37, Pg. 1633, 1986.