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Substance Name: Sparfloxacin [USAN:INN:BAN:JAN]
RN: 110871-86-8
UNII: Q90AGA787L
InChIKey: DZZWHBIBMUVIIW-DTORHVGOSA-N

Molecular Formula

  • C19-H22-F2-N4-O3

Molecular Weight

  • 392.4038
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antibacterial
  • Antineoplastic Agents
  • Antitubercular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Reproductive Effect
  • Topoisomerase II Inhibitors
  • Topoisomerase Inhibitors
  • Tuberculostatic

Names and Synonyms

Name of Substance

  • Sparfloxacin [USAN:INN:BAN:JAN]

Synonyms

  • 5-Amino-1-cyclopropyl-7-(cis-3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
  • AT 4140
  • AT-4140
  • BRN 3658018
  • CI 978
  • CI-978
  • CP 103826
  • DRG-0143
  • Esparfloxacino
  • Esparfloxacino [INN-Spanish]
  • Parox
  • PD 1315-1
  • PD 131501
  • PD-131501
  • Sparfloxacin
  • Sparfloxacine
  • Sparfloxacine [INN-French]
  • Sparfloxacinum
  • Sparfloxacinum [INN-Latin]
  • UNII-Q90AGA787L
  • Zagam

Systematic Names

  • 3-Quinolinecarboxylic acid, 1,4-dihydro-5-amino-1-cyclopropyl-6,8-difluoro-7-(3,5-dimethyl-1-piperazinyl)-4-oxo-, cis-
  • 3-Quinolinecarboxylic acid, 5-amino-1-cyclopropyl-7-((3R,5S)-3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-, rel-
  • 3-Quinolinecarboxylic acid, 5-amino-1-cyclopropyl-7-(3,5-dimethyl-1-piperazinyl)-6,8-difluoro-1,4-dihydro-4-oxo-, cis-

Registry Numbers

CAS Registry Number

  • 110871-86-8

FDA UNII

  • Q90AGA787L

System Generated Number

  • 0110871868

Structure Descriptors

InChI

1S/C19H22F2N4O3/c1-8-5-24(6-9(2)23-8)17-13(20)15(22)12-16(14(17)21)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6,22H2,1-2H3,(H,27,28)/t8-,9+

InChIKey

DZZWHBIBMUVIIW-DTORHVGOSA-N

Smiles

C[C@@H]1CN(C[C@@H](N1)C)c2c(c(c3c(c2F)n(cc(c3=O)C(=O)O)C4CC4)N)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 600mg/kg (600mg/kg)   Drugs of the Future. Vol. 14, Pg. 413, 1989.
mouse LD50 intraperitoneal > 2gm/kg (2000mg/kg)   Drugs of the Future. Vol. 14, Pg. 413, 1989.
mouse LD50 oral > 2gm/kg (2000mg/kg)   United States Patent Document. Vol. #4795751,
mouse LD50 subcutaneous > 2gm/kg (2000mg/kg)   Drugs of the Future. Vol. 14, Pg. 413, 1989.
rat LD50 intraperitoneal > 2gm/kg (2000mg/kg)   Drugs of the Future. Vol. 14, Pg. 413, 1989.
rat LD50 oral > 5gm/kg (5000mg/kg)   Drugs of the Future. Vol. 14, Pg. 413, 1989.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg)   Drugs of the Future. Vol. 14, Pg. 413, 1989.