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Substance Name: Partricin [USAN:INN]
RN: 11096-49-4
UNII: 4PWA41S89D
InChIKey: NVJUPMZQNWDHTL-GKTUUKTKSA-N

Note

  • Polyene antibiotic from Streptomyces aureofaciens; proposed as an antifungal & antiprotozoal agent.

Molecular Formula

  • Unspecified

Molecular Weight

  • 1113.2966
 

Classification Codes

  • Antifungal
  • Antiprotozoal
  • Drug / Therapeutic Agent
  • Natural Product
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Names and Synonyms

Name of Substance

  • Partricin
  • Partricin [USAN:INN]

Synonyms

  • Antibiotic spa-8-132
  • Partricin
  • Partricina
  • Partricina [INN-Spanish]
  • Partricine
  • Partricine [INN-French]
  • Partricinum
  • Partricinum [INN-Latin]
  • Spa-S 132
  • SPA-S-132
  • UNII-4PWA41S89D

Systematic Name

  • Partricin

Registry Numbers

CAS Registry Number

  • 11096-49-4

FDA UNII

  • 4PWA41S89D

System Generated Number

  • 0011096494

Structure Descriptors

InChI

1S/C58H84N2O19/c1-34-16-14-12-10-8-6-4-5-7-9-11-13-15-17-46(77-57-54(72)52(60)53(71)36(3)76-57)31-49-51(56(73)74)48(69)33-58(75,79-49)32-45(67)28-43(65)26-41(63)24-40(62)25-42(64)27-44(66)30-50(70)78-55(34)35(2)18-23-39(61)29-47(68)37-19-21-38(59)22-20-37/h4-17,19-22,34-36,39-41,43-46,48-49,51-55,57,61-63,65-67,69,71-72,75H,18,23-33,59-60H2,1-3H3,(H,73,74)/b5-4-,8-6-,9-7-,12-10-,13-11-,16-14-,17-15-/t34?,35?,36-,39?,40?,41?,43?,44?,45?,46?,48?,49?,51?,52+,53-,54+,55?,57+,58?/m0/s1

InChIKey

NVJUPMZQNWDHTL-GKTUUKTKSA-N

Smiles

C[C@H]1[C@@H]([C@H]([C@H]([C@H](O1)OC/2CC3C(C(CC(O3)(CC(CC(CC(CC(CC(=O)CC(CC(=O)OC(C(/C=C\C=C/C=C\C=C/C=C\C=C/C=C2)C)C(C)CCC(CC(=O)c4ccc(cc4)N)O)O)O)O)O)O)O)O)C(=O)O)O)N)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 500ug/kg (0.5mg/kg) BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA Experientia. Vol. 28, Pg. 1515, 1972.
mouse LD50 oral 300mg/kg (300mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 2, Pg. 1055, 1978.