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Substance Name: Ethylene glycol mono-n-butyl ether
RN: 111-76-2
UNII: I0P9XEZ9WV
InChIKey: POAOYUHQDCAZBD-UHFFFAOYSA-N

Molecular Formula

  • C6-H14-O2

Molecular Weight

  • 118.175
 

Classification Codes

Classification Codes

  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • TWA (20 ppm); Confirmed animal carcinogen with unknown relevance to humans
  • TWA 50 ppm (240 mg/m3); skin

Names and Synonyms

Name of Substance

  • 2-Butoxyethanol
  • Butoxyethanol
  • Butyl cellosolve
  • Ethanol, 2-butoxy-
  • Ethylene glycol mono-n-butyl ether
  • Ethylene glycol monobutyl ether
  • Monobutyl ethylene glycol ether
  • n-Butoxyethanol

Synonyms

  • 2-Butossi-etanolo
  • 2-Butossi-etanolo [Italian]
  • 2-Butoxy-1-ethanol
  • 2-Butoxy-aethanol
  • 2-Butoxy-aethanol [German]
  • 2-Butoxyethanol
  • 3-Oxa-1-heptanol
  • 4-01-00-02380 (Beilstein Handbook Reference)
  • AI3-09903
  • AI3-0993
  • BRN 1732511
  • BUCS
  • Butoksyetylowy alkohol
  • Butoksyetylowy alkohol [Polish]
  • Butoxyethanol
  • Butyl cellosolve
  • Butyl cellu-sol
  • Butyl glycol
  • Butyl oxitol
  • Butylcelosolv
  • Butylcelosolv [Czech]
  • Butylglycol
  • Butylglycol [French,German]
  • Caswell No. 121
  • CCRIS 5985
  • Chimec NR
  • Dowanol EB
  • EC 203-905-0
  • EGBE
  • EGMBE
  • EINECS 203-905-0
  • Ektasolve EB
  • EPA Pesticide Chemical Code 011501
  • Eter monobutilico del etilenglicol
  • Eter monobutilico del etilenglicol [Spanish]
  • Ethanol, 2-butoxy-
  • Ether monobutylique de l'ethyleneglycol
  • Ether monobutylique de l'ethyleneglycol [French]
  • Ethylene glycol butyl ether
  • Ethylene glycol monobutyl ether
  • Ethylene glycol n-butyl ether
  • Ethylene glycol, monobutyl ether
  • Gafcol EB
  • Glycol butyl ether
  • Glycol ether EB
  • Glycol monobutyl ether
  • HSDB 538
  • Jeffersol EB
  • Monobutyl ether of ethylene glycol
  • Monobutyl ethylene glycol ether
  • n-Butoxyethanol
  • NSC 60759
  • O-Butyl ethylene glycol
  • Poly-Solv EB
  • UNII-I0P9XEZ9WV

Systematic Names

  • 2-Butoxyethanol
  • Ethanol, 2-butoxy-

Superlist Names

  • 2-Butoxyethanol
  • Butoxyethanol, 2-
  • Butyl cellosolve
  • EGBE
  • Ethanol, 2-butoxy-
  • Ethylene glycol butyl ether
  • Ethylene glycol monobutyl ether
  • Ethylene glycol monobutyl ether [UN2369] [Keep away from food]
  • UN2369

Registry Numbers

CAS Registry Number

  • 111-76-2

FDA UNII

  • I0P9XEZ9WV

Other Registry Numbers

  • 107461-82-5
  • 161279-90-9

Related Registry Number

  • 52663-57-7 (hydrochloride salt)

System Generated Number

  • 0000111762

Structure Descriptors

InChI

1S/C6H14O2/c1-2-3-5-8-6-4-7/h7H,2-6H2,1H3

InChIKey

POAOYUHQDCAZBD-UHFFFAOYSA-N

Smiles

C(OCCO)CCC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LC inhalation > 633ppm/1H (633ppm)   National Technical Information Service. Vol. OTS0572613,
guinea pig LD50 oral 1200mg/kg (1200mg/kg) GASTROINTESTINAL: OTHER CHANGES

BEHAVIORAL: GENERAL ANESTHETIC

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
guinea pig LD50 skin 230uL/kg (0.23mL/kg)   Toxicology and Applied Pharmacology. Vol. 7, Pg. 559, 1965.
human TCLo inhalation 100ppm (100ppm) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. Vol. 1, Pg. 50, 1974.
human TCLo inhalation 195ppm/8H (195ppm) GASTROINTESTINAL: NAUSEA OR VOMITING AMA Archives of Industrial Health. Vol. 14, Pg. 114, 1956.
mammal (species unspecified) LD50 unreported 1500mg/kg (1500mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(5), Pg. 61, 1986.
mouse LC50 inhalation 700ppm/7H (700ppm) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ANALGESIA

KIDNEY, URETER, AND BLADDER: HEMATURIA
Journal of Industrial Hygiene and Toxicology. Vol. 25, Pg. 157, 1943.
mouse LD50 intraperitoneal 536mg/kg (536mg/kg)   Shell Chemical Company. Unpublished Report. Vol. -, Pg. 2, 1961.
mouse LD50 intravenous 1130mg/kg (1130mg/kg)   AMA Archives of Industrial Health. Vol. 14, Pg. 114, 1956.
mouse LD50 oral 1230mg/kg (1230mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
AMA Archives of Industrial Health. Vol. 14, Pg. 114, 1956.
mouse LD50 unreported 1050mg/kg (1050mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 41(11), Pg. 7, 1976.
mouse LDLo subcutaneous 500mg/kg (500mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 42, Pg. 355, 1931.
rabbit LD50 intraperitoneal 220mg/kg (220mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 67, 1982.
rabbit LD50 intravenous 252mg/kg (252mg/kg)   AMA Archives of Industrial Health. Vol. 14, Pg. 114, 1956.
rabbit LD50 oral 300mg/kg (300mg/kg)   Yakkyoku. Pharmacy. Vol. 32, Pg. 1241, 1981.
rabbit LD50 skin 220mg/kg (220mg/kg)   Dow Chemical Company Reports. Vol. MSD-46,
rat LC50 inhalation 450ppm/4H (450ppm)   Toxicology and Applied Pharmacology. Vol. 68, Pg. 405, 1983.
rat LC50 inhalation 450ppm/4H (450ppm) BEHAVIORAL: ATAXIA Toxicology and Applied Pharmacology. Vol. 68, Pg. 405, 1983.
rat LD50 intraperitoneal 220mg/kg (220mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 67, 1982.
rat LD50 intravenous 307mg/kg (307mg/kg)   AMA Archives of Industrial Health. Vol. 14, Pg. 114, 1956.
rat LD50 oral 470mg/kg (470mg/kg)   Dow Chemical Company Reports. Vol. MSD-46,
rat LD50 unreported 917mg/kg (917mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 41(11), Pg. 7, 1976.
women TDLo oral 7813uL/kg (7.813mL/kg) BEHAVIORAL: COMA

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Human Toxicology. Vol. 8, Pg. 243, 1989.
women TDLo oral 600mg/kg (600mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: COMA
Human Toxicology. Vol. 7, Pg. 187, 1988.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -7.48E+01 deg C   EXP
Boiling Point 168.4 deg C   EXP
log P (octanol-water) 0.83 (none)   EXP
Water Solubility 1.00E+06 mg/L 20 EXP
Vapor Pressure 0.88 mm Hg 25 EXP
Henry's Law Constant 1.60E-06 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 1.86E-11 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.