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Substance Name: Diethylene glycol monoethyl ether [NF]
RN: 111-90-0
UNII: A1A1I8X02B
InChIKey: XXJWXESWEXIICW-UHFFFAOYSA-N

Note

  • Used as lubricating oil & in braking fluid.

Molecular Formula

  • C6-H14-O3

Molecular Weight

  • 134.174
 

Classification Codes

  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
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Names and Synonyms

Name of Substance

  • 2-(2-Ethoxyethoxy)ethanol
  • Carbitol
  • Diethylene glycol monoethyl ether
  • Diethylene glycol monoethyl ether [NF]
  • Ethanol, 2-(2-ethoxyethoxy)-
  • Ethoxydiglycol

Synonyms

  • 2-(2-Ethoxyethoxy) ethanol
  • 2-(2-Ethoxyethoxy)ethanol
  • 3,6-Dioxa-1-octanol
  • 3,6-Dioxa-1-oktanol
  • 3,6-Dioxa-1-oktanol [Czech]
  • 4-01-00-02393 (Beilstein Handbook Reference)
  • Aethyldiaethylenglycol
  • Aethyldiaethylenglycol [German]
  • AI3-01740
  • BRN 1736441
  • Carbitol
  • Carbitol cellosolve
  • Carbitol solvent
  • DEGMEE
  • Diethylene glycol ethyl ether
  • Diethylene glycol monoethyl ether
  • Diethyleneglycol monoethyl ether
  • Diglycol monoethyl ether
  • Dioxitol
  • Dowanol 17
  • Dowanol DE
  • EC 203-919-7
  • EINECS 203-919-7
  • Ektasolve DE
  • Ethanol, 2,2'-oxybis-, monoethyl ether
  • Ethanol, 2-(2-ethoxyethoxy)-
  • Ethoxy diglycol
  • Ethyl carbitol
  • Ethyl diethylene glycol
  • Ethyl digol
  • Ethylene diglycol monoethyl ether
  • HSDB 51
  • Karbitol
  • Karbitol [Czech]
  • Losungsmittel APV
  • Monoethyl ether of diethylene glycol
  • NSC 408451
  • PM 1799
  • Poly-Solv DE
  • Solvolsol
  • Transcutol
  • Transcutol P
  • UNII-A1A1I8X02B

Systematic Names

  • 2-(2-Ethoxyethoxy)ethanol
  • Ethanol, 2-(2-ethoxyethoxy)-

Superlist Names

  • Diethylene glycol ethyl ether
  • Diethylene glycol monoethyl ether
  • Ethanol, 2-(2-ethoxyethoxy)-

Registry Numbers

CAS Registry Number

  • 111-90-0

FDA UNII

  • A1A1I8X02B

System Generated Number

  • 0000111900

Structure Descriptors

InChI

1S/C6H14O3/c1-2-8-5-6-9-4-3-7/h7H,2-6H2,1H3

InChIKey

XXJWXESWEXIICW-UHFFFAOYSA-N

Smiles

C(COCC)OCCO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 1gm/kg (1000mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1571, 1978.
dog LD50 intravenous 3mL/kg (3mL/kg) BEHAVIORAL: COMA

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Industrial Hygiene and Toxicology. Vol. 29, Pg. 190, 1947.
guinea pig LD50 oral 3700uL/kg (3.7mL/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.
guinea pig LD50 skin > 32gm/kg (32000mg/kg)   National Technical Information Service. Vol. OTS0516797,
guinea pig LD50 unreported 3gm/kg (3000mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(4), Pg. 74, 1981.
mouse LD50 intraperitoneal 2300mg/kg (2300mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Pharmacology and Therapeutics. Vol. 5, Pg. 467, 1979.
mouse LD50 intravenous 4300uL/kg (4.3mL/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 65, Pg. 89, 1939.
mouse LD50 oral 6600uL/kg (6.6mL/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: COMA
Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.
mouse LD50 skin 6mL/kg (6mL/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: COMA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of Industrial Hygiene and Toxicology. Vol. 29, Pg. 190, 1947.
mouse LD50 subcutaneous 5500uL/kg (5.5mL/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 65, Pg. 89, 1939.
mouse LD50 unreported 7150mg/kg (7150mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(2), Pg. 14, 1981.
rabbit LD50 intravenous 2500uL/kg (2.5mL/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: COMA
Journal of Industrial Hygiene and Toxicology. Vol. 29, Pg. 190, 1947.
rabbit LD50 oral 3620mg/kg (3620mg/kg)   National Technical Information Service. Vol. OTS0516797,
rabbit LD50 skin 4200uL/kg (4.2mL/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" National Technical Information Service. Vol. OTS0516797,
rat LC50 inhalation > 5240mg/m3/4H (5240mg/m3) LIVER: OTHER CHANGES BG Chemie: Toxicological Evaluations, Five Potential Health Hazards of Existing Chemicals. Vol. 5, Pg. 91, 1993.
rat LD50 intraperitoneal 360ug/kg (0.36mg/kg)   National Technical Information Service. Vol. OTS0516797,
rat LD50 intravenous 4gm/kg (4000mg/kg)   National Technical Information Service. Vol. OTS0516797,
rat LD50 oral 5500uL/kg (5.5mL/kg) BEHAVIORAL: COMA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Journal of Industrial Hygiene and Toxicology. Vol. 21, Pg. 173, 1939.
rat LD50 skin 6mL/kg (6mL/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

BEHAVIORAL: COMA
Journal of Industrial Hygiene and Toxicology. Vol. 29, Pg. 190, 1947.
rat LD50 subcutaneous 6gm/kg (6000mg/kg)   Bollettino Chimico Farmaceutico. Vol. 125, Pg. 401, 1986.
rat LD50 unreported 7500mg/kg (7500mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: EXCITEMENT
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 46(4), Pg. 74, 1981.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -7.60E+01 deg C   EXP
Boiling Point 196 deg C   EXP
log P (octanol-water) -0.54 (none)   EXP
Water Solubility 1.00E+06 mg/L 20 EXP
Vapor Pressure 0.126 mm Hg 25 EXP
Henry's Law Constant 2.23E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 5.72E-11 cm3/molecule-sec 23 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.