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Substance Name: Bietaserpine bitartrate
RN: 1111-44-0
UNII: 20AY3RFI45
InChIKey: FIVIJZLAHKBGLP-PDHAJTERSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formulas

  • C39-H53-N3-O9.2C4-H6-O6
  • C39-H53-N3-O9.C4-H6-O6

Molecular Weight

  • 856.957
 
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Names and Synonyms

Name of Substance

  • Bietaserpine bitartrate

Synonyms

  • 1-(2-(Diethylamino)ethyl)reserpine bitartrate
  • Bietaserpine bitartrate
  • Bitartrate acide de N-diethylamino ethyl-reserpine
  • Bitartrate acide de N-diethylamino ethyl-reserpine [French]
  • D. L. 152
  • EINECS 214-180-5
  • Pleiatensin
  • RTECS ZH7658000
  • Tensibar
  • UNII-20AY3RFI45

Systematic Names

  • 3-beta,20-alpha-Yohimban-16-beta-carboxylic acid, 1-(2-(diethylamino)ethyl)-18-beta-hydroxy-11,17-alpha-dimethoxy-, methyl ester, 3,4,5-trimethoxybenzoate (ester), tartrate (1:2)
  • Yohimban-16-carboxylic acid, 1-(2-(diethylamino)ethyl)-11,17-dimethoxy-18-((3,4,5-trimethoxybenzoyl)oxy)-, methyl ester, (3beta,16beta,17alpha,18beta,20alpha)-, (R-(R*,R*))-2,3-dihydroxybutanedionate (1:1)

Registry Numbers

CAS Registry Number

  • 1111-44-0

FDA UNII

  • 20AY3RFI45

Other Registry Numbers

  • 17925-91-6
  • 23618-66-8

System Generated Number

  • 0001111440

Molecular Formulas

Molecular Formulas

  • C39-H53-N3-O9.2C4-H6-O6
  • C39-H53-N3-O9.C4-H6-O6

Molecular Formula Fragments

  • C39-H53-N3-O9
  • C4-H6-O6
  • COMPONENT

Structure Descriptors

InChI

1S/C40H54N2O9.C4H6O6/c1-9-41(10-2)15-16-42-31-21-26(45-3)12-14-27(31)28-13-11-23-17-24-18-34(38(49-7)35(40(44)50-8)29(24)22-30(23)36(28)42)51-39(43)25-19-32(46-4)37(48-6)33(20-25)47-5;5-1(3(7)8)2(6)4(9)10/h12,14,19-21,23-24,29-30,34-35,38H,9-11,13,15-18,22H2,1-8H3;1-2,5-6H,(H,7,8)(H,9,10)/t23?,24-,29-,30-,34+,35-,38-;1-,2-/m01/s1

InChIKey

FIVIJZLAHKBGLP-PDHAJTERSA-N

Smiles

c1cc2c3c(n(c2cc1OC)CCN(CC)CC)[C@@H]1[C@@H](CC3)C[C@@H]2[C@H](C1)[C@@H]([C@H]([C@@H](C2)OC(c1cc(c(c(c1)OC)OC)OC)=O)OC)C(=O)OC.OC([C@@H]([C@H](C(O)=O)O)O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 430mg/kg (430mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 1040, 1964.
mouse LD50 intravenous 215mg/kg (215mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 1040, 1964.
mouse LD50 oral 620mg/kg (620mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 1040, 1964.
mouse LD50 subcutaneous 1061mg/kg (1061mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 81, 1971.
rat LD50 intraperitoneal 496mg/kg (496mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 81, 1971.
rat LD50 oral 4885mg/kg (4885mg/kg) BEHAVIORAL: TREMOR

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 81, 1971.
rat LD50 subcutaneous 888mg/kg (888mg/kg) BEHAVIORAL: FOOD INTAKE (ANIMAL)

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Kiso to Rinsho. Clinical Report. Vol. 5, Pg. 81, 1971.