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Substance Name: Enramycin [INN]
RN: 11115-82-5
UNII: 4GP7CLG9EG
InChIKey: NJCUSQKMYNTYOW-MWUYRYRWSA-N

Note

  • Isolated from cultures of Streptomyces fungicidicus.

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C107-H140-Cl2-N26-O32

Molecular Weight

  • 2373.339
 
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Names and Synonyms

Name of Substance

  • Enramycin
  • Enramycin [INN]

Synonyms

  • Enduracidin
  • Enradin
  • Enramicina
  • Enramicina [INN-Spanish]
  • Enramycin
  • Enramycinum
  • Enramycinum [INN-Latin]
  • UNII-4GP7CLG9EG

Systematic Names

  • Antibiotic obtained from cultures of Streptomyces fungicidicus B 5477, or the same substance produced by any other means
  • Enduracidin

Registry Numbers

CAS Registry Number

  • 11115-82-5

FDA UNII

  • 4GP7CLG9EG

Other Registry Number

  • 12772-37-1

System Generated Number

  • 0011115825

Structure Descriptors

InChI

1S/C107H138Cl2N26O31.H2O/c1-7-51(2)17-12-10-8-9-11-13-19-76(144)120-74(47-77(145)146)92(152)126-80-55(6)166-102(162)86(60-28-38-68(143)39-29-60)132-88(148)52(3)117-90(150)73(46-63-49-116-104(112)119-63)124-106(164)134-100(160)84(61-43-69(108)87(147)70(109)44-61)128-93(153)75(50-136)123-97(157)81(56-20-30-64(139)31-21-56)127-91(151)72(45-62-48-115-103(111)118-62)122-89(149)71(18-16-41-114-105(113)163)121-94(154)78(53(4)137)125-98(158)82(57-22-32-65(140)33-23-57)130-99(159)83(58-24-34-66(141)35-25-58)129-95(155)79(54(5)138)133-107(165)135(42-15-14-40-110)101(161)85(131-96(80)156)59-26-36-67(142)37-27-59;/h9,11,13,19-39,43-44,51-55,62-63,71-75,78-86,136-143,147H,7-8,10,12,14-18,40-42,45-50,110H2,1-6H3,(H,117,150)(H,120,144)(H,121,154)(H,122,149)(H,123,157)(H,125,158)(H,126,152)(H,127,151)(H,128,153)(H,129,155)(H,130,159)(H,131,156)(H,132,148)(H,133,165)(H,145,146)(H3,111,115,118)(H3,112,116,119)(H3,113,114,163)(H2,124,134,160,164);1H2/b11-9+,19-13+;

InChIKey

NJCUSQKMYNTYOW-MWUYRYRWSA-N

Smiles

N1(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(=O)NC(C(=O)NC(C(=O)NC(C(=O)OC(C(C(=O)NC(C1=O)c1ccc(cc1)O)NC(=O)C(CC(=O)O)NC(=O)/C=C\C=C\CCCCC(CC)C)C)c1ccc(cc1)O)C)CC1N=C(NC1)N)c1cc(c(c(c1)Cl)O)Cl)CO)c1ccc(cc1)O)CC1N=C(NC1)N)CCCNC(=O)N)C(O)C)c1ccc(cc1)O)c1ccc(cc1)O)C(O)C)CCCCN.O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 100mg/kg (100mg/kg)   Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969.
mouse LD50 intramuscular > 5gm/kg (5000mg/kg)   Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969.
mouse LD50 intraperitoneal 750mg/kg (750mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR
Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969.
mouse LD50 intravenous 30mg/kg (30mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR
Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969.
mouse LD50 oral > 10gm/kg (10000mg/kg)   Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg)   Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969.
rabbit LD50 intravenous 92mg/kg (92mg/kg)   Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969.
rat LD50 intramuscular > 5gm/kg (5000mg/kg)   Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969.
rat LD50 intraperitoneal 830mg/kg (830mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA

BEHAVIORAL: TREMOR
Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969.
rat LD50 intravenous 66600ug/kg (66.6mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: ATAXIA
Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969.
rat LD50 oral > 10gm/kg (10000mg/kg)   Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Takeda Kenkyusho Nempo. Annual Report of the Takeda Research Laboratories. Vol. 28, Pg. 76, 1969.