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Substance Name: Mepartricin [USAN:INN:BAN]
RN: 11121-32-7
UNII: B7FBW3Y74G
InChIKey: GTBKZCQTNWWEIB-PBSBGHGNSA-N

Note

  • Polyene macrolide antibiotic with unknown composition. It is obtained from Streptomyces aureofaciens. It is used as an antifungal agent, an antiprotozoal agent, and in the treatment of BENIGN PROSTATIC HYPERTROPHY.

Molecular Formula

  • Unspecified

Molecular Weight

  • 1141.3502
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antifungal
  • Antifungal Agents
  • Antiparasitic Agents
  • Antiprotozoal
  • Antiprotozoal Agents
  • Drug / Therapeutic Agent
  • Natural Product
  • Urological Agents
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Names and Synonyms

Name of Substance

  • Mepartricin
  • Mepartricin [USAN:INN:BAN]

MeSH Heading

  • Mepartricin

Synonyms

  • Ipertrofan
  • Mepartricin
  • Mepartricina
  • Mepartricina [INN-Spanish]
  • Mepartricine
  • Mepartricine [INN-French]
  • Mepartricinum
  • Mepartricinum [INN-Latin]
  • Methylpartricin
  • Orofungin
  • SN 654
  • SN654
  • Spa-S-160
  • Tricandil
  • Tricangine
  • UNII-B7FBW3Y74G

Systematic Names

  • Partricin, methyl ester
  • Partricin, methyl-

Registry Numbers

CAS Registry Number

  • 11121-32-7

FDA UNII

  • B7FBW3Y74G

Other Registry Number

  • 12795-77-6

System Generated Number

  • 0011121327

Structure Descriptors

InChI

1S/C60H88N2O19/c1-36-19-17-15-13-11-9-7-6-8-10-12-14-16-18-20-50(79-59-55(74)53(61)54(73)38(3)78-59)57-52(58(75)77-5)49(71)35-60(76,81-57)34-47(69)31-45(67)29-43(65)27-42(64)28-44(66)30-46(68)33-51(72)80-56(36)37(2)21-26-41(63)32-48(70)39-22-24-40(62-4)25-23-39/h6-19,22-25,36-38,41-43,45-47,49-50,52-57,59,62-65,67-69,71,73-74,76H,20-21,26-35,61H2,1-5H3/b7-6-,10-8+,11-9-,14-12+,15-13+,18-16+,19-17+/t36?,37?,38-,41?,42?,43?,45?,46?,47?,49?,50?,52?,53+,54-,55+,56?,57?,59?,60?/m1/s1

InChIKey

GTBKZCQTNWWEIB-PBSBGHGNSA-N

Smiles

C12(OC(C(C(C1)O)C(=O)OC)C(OC1[C@H]([C@H]([C@@H]([C@H](O1)C)O)N)O)CC=CC=CC=CC=CC=CC=CC=CC(C(OC(=O)CC(CC(=O)CC(CC(CC(CC(C2)O)O)O)O)O)C(CCC(CC(=O)c1ccc(NC)cc1)O)C)C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 11100ug/kg (11.1mg/kg)   Journal of Pharmaceutical Sciences. Vol. 65, Pg. 905, 1976.
mouse LD50 intravenous 4300ug/kg (4.3mg/kg)   Journal of Pharmaceutical Sciences. Vol. 65, Pg. 905, 1976.
mouse LD50 oral > 2gm/kg (2000mg/kg)   Farmaco, Edizione Scientifica. Vol. 33, Pg. 21, 1978.