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Substance Name: Ceronapril [USAN:INN]
RN: 111223-26-8
UNII: X3MM60SOVP
InChIKey: IFYLTXNCFVRALQ-OALUTQOASA-N

Classification Codes

  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Protease Inhibitors
  • Reproductive Effect

Molecular Formula

  • C21-H33-N2-O6-P

Molecular Weight

  • 440.4737
 
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Names and Synonyms

Name of Substance

  • Ceronapril
  • Ceronapril [USAN:INN]

Synonyms

  • (S)-1-(6-Amino-2-((hydroxy(4-phenylbutyl)phosphinyl)oxy)-1-oxohexyl)-L-proline
  • 1-((2S)-6-Amino-2-hydroxyhexanoyl)-L-proline, hydrogen (4-phenylbutyl)phosphonate (ester)
  • BRN 3635091
  • Ceronapril
  • Ceronaprilum
  • Ceronaprilum [INN-Latin]
  • L-Proline, 1-(6-amino-2-((hydroxy(4-phenylbutyl)phosphinyl)oxy)-1-oxohexyl)-, (S)-
  • SQ 29,852
  • SQ 29852
  • UNII-X3MM60SOVP

Systematic Name

  • L-Proline, 1-(6-amino-2-((hydroxy(4-phenylbutyl)phosphinyl)oxy)-1-oxohexyl)-, (S)-

Registry Numbers

CAS Registry Number

  • 111223-26-8

FDA UNII

  • X3MM60SOVP

System Generated Number

  • 0111223268

Structure Descriptors

InChI

1S/C21H33N2O6P/c22-14-6-4-13-19(20(24)23-15-8-12-18(23)21(25)26)29-30(27,28)16-7-5-11-17-9-2-1-3-10-17/h1-3,9-10,18-19H,4-8,11-16,22H2,(H,25,26)(H,27,28)/t18-,19-/m0/s1

InChIKey

IFYLTXNCFVRALQ-OALUTQOASA-N

Smiles

NCCCC[C@H](OP(=O)(O)CCCCc1ccccc1)C(=O)N2CCC[C@H]2C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD oral > 1gm/kg (1000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 379, 1992.
rat LD50 oral > 5gm/kg (5000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20, Pg. 3875, 1992.
rat LDLo intravenous 2500mg/kg (2500mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 20, Pg. 3875, 1992.