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Substance Name: Angiotensin II
RN: 11128-99-7
InChIKey: CZGUSIXMZVURDU-UHFFFAOYSA-N

Note

  • An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.

Molecular Formula

  • C50-H71-N13-O12

Molecular Weight

  • 1046.19
 

Classification Codes

  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • Vasoconstrictor Agents
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Names and Synonyms

Name of Substance

  • Angiotensin II

MeSH Heading

  • Angiotensin II

Synonyms

  • 1-8-Angiotensin I
  • 1-L-Aspasaginyl-5-L-valyl angiotensin octapeptide
  • Angiotensin II
  • Angiotensina II
  • Angiotensina II [INN-Spanish]
  • Angiotensinum II
  • Angiotensinum II [INN-Latin]

Systematic Name

  • Angiotensin II

Registry Numbers

CAS Registry Number

  • 11128-99-7

System Generated Number

  • 0011128997

Structure Descriptors

InChI

1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)

InChIKey

CZGUSIXMZVURDU-UHFFFAOYSA-N

Smiles

N1([C@@H](C(N[C@@H](Cc2ccccc2)C(O)=O)=O)CCC1)C([C@@H](Cc1c[nH]cn1)NC([C@@H](NC([C@@H](Cc1ccc(O)cc1)NC([C@@H](NC([C@@H](NC([C@@H](CC(O)=O)N)=O)CCCNC(N)=N)=O)C(C)C)=O)=O)[C@@H](CC)C)=O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 30800ug/kg (30.8mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 6079, 1990.
rat LD50 intravenous 17400ug/kg (17.4mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 6079, 1990.