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Substance Name: Amlodipine besylate [USAN:USP]
RN: 111470-99-6
UNII: 864V2Q084H
InChIKey: ZPBWCRDSRKPIDG-UHFFFAOYSA-N

Classification Codes

  • Anti-Anginal
  • Antihypertensive
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect

Molecular Formula

  • C20-H25-Cl-N2-O5.C6-H6-O3-S

Molecular Weight

  • 567.0559
 
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Names and Synonyms

Name of Substance

  • Amlodipine besylate [USAN:USP]

Synonyms

  • 3-Ethyl 5-methyl (+-)-2-((2-aminoethoxy)methyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, monobenzenesulfonate
  • Amcard
  • Amdepin
  • Amdipin
  • Amlodin
  • Amlodipine benzenesulfonate
  • Amlodipine besilate
  • Amlodipine besylate
  • Amlogard
  • Amlopin
  • Amlosyn
  • Antacal
  • Astudar
  • Cardiorex
  • Cordarene
  • Istin
  • Monopina
  • Myodura
  • Norlopin
  • Norvas
  • Norvasc
  • Norvask
  • NSC 758922
  • Pelmec
  • Stamlo
  • Tensivask
  • Terloc
  • UK 48340-26
  • UK-48,340-26
  • UNII-864V2Q084H

Systematic Names

  • 3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (+-)-, monobenzenesulfonate
  • 3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl-5-methyl ester, monobenzenesulfonate

Mixture Names

  • Azor
  • Caduet

Registry Numbers

CAS Registry Number

  • 111470-99-6

FDA UNII

  • 864V2Q084H

System Generated Number

  • 0111470996

Molecular Formulas

Molecular Formula

  • C20-H25-Cl-N2-O5.C6-H6-O3-S

Molecular Formula Fragments

  • C20-H25-Cl-N2-O5
  • C6-H6-O3-S
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)

InChIKey

ZPBWCRDSRKPIDG-UHFFFAOYSA-N

Smiles

CCOC(=O)C1=C(COCCN)NC(=C(C1c2ccccc2Cl)C(=O)OC)C.OS(=O)(=O)c3ccccc3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 10mg/kg (10mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 1169, 1994.
man TDLo oral 1429ug/kg (1.429mg/kg) LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA

VASCULAR: SHOCK

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"		 American Journal of Emergency Medicine. Vol. 16, Pg. 527, 1998.
mouse LD50 intraperitoneal 31mg/kg (31mg/kg)   Drugs in Japan Vol. -, Pg. 71, 1995.
mouse LD50 oral 37mg/kg (37mg/kg)   Drugs in Japan Vol. -, Pg. 71, 1995.
mouse LD50 subcutaneous 36mg/kg (36mg/kg)   Drugs in Japan Vol. -, Pg. 71, 1995.
rat LD50 intraperitoneal 42mg/kg (42mg/kg)   Drugs in Japan Vol. -, Pg. 71, 1995.
rat LD50 oral 393mg/kg (393mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BLOOD: OTHER CHANGES		 Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 177, 1991.
rat LD50 subcutaneous 678mg/kg (678mg/kg)   Drugs in Japan Vol. -, Pg. 71, 1995.
women TDLo oral 1mg/kg (1mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION		 Annals of Pharmacotherpy. Vol. 31, Pg. 853, 1997.
women TDLo unreported 6mg/kg/60D-I (6mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION Lancet. Vol. 341, Pg. 1102, 1993.