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Substance Name: Amlodipine besylate [USAN:USP]
RN: 111470-99-6
UNII: 864V2Q084H
InChIKey: ZPBWCRDSRKPIDG-UHFFFAOYSA-N
Classification Codes
- Anti-Anginal
- Antihypertensive
- Drug / Therapeutic Agent
- Human Data
- Reproductive Effect
Molecular Formula
- C20-H25-Cl-N2-O5.C6-H6-O3-S
Molecular Weight
- 567.0559
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Names and Synonyms
Name of Substance
- Amlodipine besylate [USAN:USP]
Synonyms
- 3-Ethyl 5-methyl (+-)-2-((2-aminoethoxy)methyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, monobenzenesulfonate
- Amcard
- Amdepin
- Amdipin
- Amlodin
- Amlodipine benzenesulfonate
- Amlodipine besilate
- Amlodipine besylate
- Amlogard
- Amlopin
- Amlosyn
- Antacal
- Astudar
- Cardiorex
- Cordarene
- Istin
- Monopina
- Myodura
- Norlopin
- Norvas
- Norvasc
- Norvask
- NSC 758922
- Pelmec
- Stamlo
- Tensivask
- Terloc
- UK 48340-26
- UK-48,340-26
- UNII-864V2Q084H
Systematic Names
- 3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (+-)-, monobenzenesulfonate
- 3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl-5-methyl ester, monobenzenesulfonate
Mixture Names
- Azor
- Caduet
Registry Numbers
CAS Registry Number
- 111470-99-6
FDA UNII
- 864V2Q084H
System Generated Number
- 0111470996
Molecular Formulas
Molecular Formula
- C20-H25-Cl-N2-O5.C6-H6-O3-S
Molecular Formula Fragments
- C20-H25-Cl-N2-O5
- C6-H6-O3-S
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C20H25ClN2O5.C6H6O3S/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21;7-10(8,9)6-4-2-1-3-5-6/h5-8,17,23H,4,9-11,22H2,1-3H3;1-5H,(H,7,8,9)InChIKey
ZPBWCRDSRKPIDG-UHFFFAOYSA-NSmiles
CCOC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | oral | 10mg/kg (10mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 36, Pg. 1169, 1994. |
man | TDLo | oral | 1429ug/kg (1.429mg/kg) | LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA VASCULAR: SHOCK KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | American Journal of Emergency Medicine. Vol. 16, Pg. 527, 1998. |
mouse | LD50 | intraperitoneal | 31mg/kg (31mg/kg) | Drugs in Japan Vol. -, Pg. 71, 1995. | |
mouse | LD50 | oral | 37mg/kg (37mg/kg) | Drugs in Japan Vol. -, Pg. 71, 1995. | |
mouse | LD50 | subcutaneous | 36mg/kg (36mg/kg) | Drugs in Japan Vol. -, Pg. 71, 1995. | |
rat | LD50 | intraperitoneal | 42mg/kg (42mg/kg) | Drugs in Japan Vol. -, Pg. 71, 1995. | |
rat | LD50 | oral | 393mg/kg (393mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BLOOD: OTHER CHANGES | Oyo Yakuri. Pharmacometrics. Vol. 42, Pg. 177, 1991. |
rat | LD50 | subcutaneous | 678mg/kg (678mg/kg) | Drugs in Japan Vol. -, Pg. 71, 1995. | |
women | TDLo | oral | 1mg/kg (1mg/kg) | CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION | Annals of Pharmacotherpy. Vol. 31, Pg. 853, 1997. |
women | TDLo | unreported | 6mg/kg/60D-I (6mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER CHANGES: OLFACTION | Lancet. Vol. 341, Pg. 1102, 1993. |