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Substance Name: Metformin hydrochloride [USAN:USP:JAN]
RN: 1115-70-4
UNII: 786Z46389E
InChIKey: OETHQSJEHLVLGH-UHFFFAOYSA-N

Note

  • A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)

Molecular Formula

  • C4-H11-N5.Cl-H

Molecular Weight

  • 165.6268
 

Classification Codes

  • Antidiabetic
  • Drug / Therapeutic Agent
  • Skin / Eye Irritant

Names and Synonyms

Name of Substance

  • Metformin hydrochloride
  • Metformin hydrochloride [USAN:USP:JAN]

Synonyms

  • 1,1-Dimethylbiguanide hydrochloride
  • 1,1-Dimethylbiguanide monohydrochloride
  • AI3-51264
  • Apo-Metformin
  • Benofomin
  • Biocos
  • Cidophage
  • D 15095
  • D.B.I.
  • Dabex
  • Denkaform
  • Dextin
  • Diabefagos
  • Diaberit
  • Diabesin
  • Diabetex
  • Diabetmin
  • Diaformin
  • Diamin
  • Diaphage
  • Diformin
  • Diformin Retard
  • Dimethylbiguanide hydrochloride
  • DMGG hydrochloride
  • EC 214-230-6
  • EINECS 214-230-6
  • Fornidd
  • Fortamet
  • Geamet
  • Glibomet
  • Glucofago
  • Glucoform
  • Glucoliz
  • Glucomet
  • Glucomine
  • Gluconil
  • Glucophage
  • Glucophage 850
  • Glucophage Forte
  • Glucophage Retard
  • Glucophage XR
  • Glucophage-Mite
  • Gluformin
  • Glumetza
  • Glupermin
  • Glyciphage
  • Glycoran
  • Glyformin
  • Haurymellin hydrochloride
  • HSDB 7080
  • Imidodicarbonimidic diamide, N,N-dimethyl-, monohydrochloride
  • Islotin retard
  • LA 6023
  • LA-6023
  • Meglucon
  • Meguan
  • Mescorit
  • Metbay
  • Metforal
  • Metformin HCl
  • Metformin HCl ER
  • Metformin hydrochloride
  • Metformin monohydrochloride
  • Metiguanide monohydrochloride
  • Metolmin
  • Metomin
  • N,N-Dimethylbiguanide hydrochloride
  • N1,N1-Dimethylbiguanide hydrochloride
  • Novo-Metformin
  • NSC 91485
  • Orabet
  • Riomet
  • Risidon
  • Siamformet
  • Thiabet
  • UNII-786Z46389E
  • Walaphage

Systematic Names

  • Biguanide, 1,1-dimethyl-, hydrochloride
  • Biguanide, 1,1-dimethyl-, monohydrochloride (8CI)
  • Imidodicarbonimidic diamide, N,N-dimethyl-, monohydrochloride (9CI)
  • Metformin hydrochloride

Mixture Names

  • Janumet
  • Metaglip

Registry Numbers

CAS Registry Number

  • 1115-70-4

FDA UNII

  • 786Z46389E

Other Registry Numbers

  • 144377-16-2
  • 15537-72-1
  • 56258-19-6

System Generated Number

  • 0001115704

Molecular Formulas

Molecular Formula

  • C4-H11-N5.Cl-H

Molecular Formula Fragments

  • C4-H11-N5
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H

InChIKey

OETHQSJEHLVLGH-UHFFFAOYSA-N

Smiles

CN(C)C(=N)NC(=N)N.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intramuscular 200mg/kg (200mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 474, 1960.
guinea pig LD50 intraperitoneal 200mg/kg (200mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 474, 1960.
guinea pig LD50 oral 500mg/kg (500mg/kg)   Drugs in Japan Vol. -, Pg. 1193, 1990.
guinea pig LD50 subcutaneous 150mg/kg (150mg/kg)   Drugs in Japan Vol. -, Pg. 1193, 1990.
mouse LD50 intraperitoneal 420mg/kg (420mg/kg)   Drugs in Japan Vol. 6, Pg. 841, 1982.
mouse LD50 intravenous 180mg/kg (180mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04012,
mouse LD50 oral 1450mg/kg (1450mg/kg)   Drugs in Japan Vol. 6, Pg. 841, 1982.
mouse LD50 subcutaneous 225mg/kg (225mg/kg)   Drugs in Japan Vol. -, Pg. 1193, 1990.
rabbit LD50 oral 350mg/kg (350mg/kg)   Drugs in Japan Vol. -, Pg. 1193, 1990.
rabbit LD50 subcutaneous 150mg/kg (150mg/kg)   Drugs in Japan Vol. -, Pg. 1193, 1990.
rat LD50 intraperitoneal 500mg/kg (500mg/kg)   French Demande Patent Document. Vol. #2220256,
rat LD50 oral 1gm/kg (1000mg/kg)   "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 934, 1989.
rat LD50 subcutaneous 300mg/kg (300mg/kg)   "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 934, 1989.