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Substance Name: Satigrel [INN]
RN: 111753-73-2
UNII: XPV71VQL72
InChIKey: GRVCTHTXJDYIHB-UHFFFAOYSA-N

Classification Codes

  • Hematologic Agents
  • Mutation Data
  • Platelet Aggregation Inhibitors
  • Reproductive Effect

Molecular Formula

  • C20-H19-N-O4

Molecular Weight

  • 337.373
 
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Names and Synonyms

Name of Substance

  • Satigrel
  • Satigrel [INN]

Synonyms

  • 5,5-Bis(4-methoxyphenyl)-4-cyano-4-pentenoic acid
  • CCRIS 7283
  • E 5510
  • E5510
  • Satigrel
  • UNII-XPV71VQL72

Systematic Names

  • 4-Cyano-5,5-bis(p-methoxyphenyl)-4-pentenoic acid
  • 4-Pentenoic acid, 4-cyano-5,5-bis(4-methoxyphenyl)-
  • 4-Pentenoic acid, 5,5-bis(4-methoxyphenyl)-4-cyano-
  • E5510

Registry Numbers

CAS Registry Number

  • 111753-73-2

FDA UNII

  • XPV71VQL72

System Generated Number

  • 0111753732

Structure Descriptors

InChI

1S/C20H19NO4/c1-24-17-8-3-14(4-9-17)20(16(13-21)7-12-19(22)23)15-5-10-18(25-2)11-6-15/h3-6,8-11H,7,12H2,1-2H3,(H,22,23)

InChIKey

GRVCTHTXJDYIHB-UHFFFAOYSA-N

Smiles

COc1ccc(cc1)\C(=C(/C#N)CCC(=O)O)c1ccc(cc1)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 1gm/kg (1000mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

BLOOD: CHANGES IN PLATELET COUNT
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 4811, 1994.
mouse LD50 intraperitoneal 342mg/kg (342mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 4801, 1994.
mouse LD50 oral 891mg/kg (891mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 4801, 1994.
mouse LD50 subcutaneous 839mg/kg (839mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 4801, 1994.
rat LD50 intraperitoneal 220mg/kg (220mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 4801, 1994.
rat LD50 oral 337mg/kg (337mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 4801, 1994.
rat LD50 subcutaneous 445mg/kg (445mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 22, Pg. 4801, 1994.