Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Flobufen
RN: 112344-52-2
UNII: 0LNC8EZT75
InChIKey: FIKVYIRIUOFLLR-UHFFFAOYSA-N

Note

  • Antirheumatic drug.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C17-H14-F2-O3

Molecular Weight

  • 304.291
 
* denotes mobile formatted website

Links to Resources

NLM Resources (File Locators)

Other Resources (Internet Locators)


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Flobufen

Synonyms

  • 2',4'-Difluoro-alpha-methyl-gamma-oxo-(1,1'-biphenyl)-4-butanoic acid
  • 3-(4-(2,4-Difluorophenyl)benzoyl)-2-methylpropionic acid
  • 4-(2',4'-Difluorbiphenyl-4-yl)-2-methyl-4-oxobutansaeure
  • 4-(2',4'-Difluorbiphenyl-4-yl)-2-methyl-4-oxobutansaeure [German]
  • 4-(2',4'-Difluorobiphenylyl)-4-oxo-2-methylbutanoic acid
  • BRN 4522244
  • Flobufen
  • gamma-Oxo-(2',4'-difluoro-(1,1')-biphenyl-4-yl)-2-methylbutanoic acid
  • UNII-0LNC8EZT75
  • VUFB16066

Systematic Name

  • (1,1'-Biphenyl)-4-butanoic acid, 2',4'-difluoro-alpha-methyl-gamma-oxo-

Registry Numbers

CAS Registry Number

  • 112344-52-2

FDA UNII

  • 0LNC8EZT75

System Generated Number

  • 0112344522

Structure Descriptors

InChI

1S/C17H14F2O3/c1-10(17(21)22)8-16(20)12-4-2-11(3-5-12)14-7-6-13(18)9-15(14)19/h2-7,9-10H,8H2,1H3,(H,21,22)

InChIKey

FIKVYIRIUOFLLR-UHFFFAOYSA-N

Smiles

c1(ccc(cc1)C(C[C@@H](C(=O)O)C)=O)c1c(cc(cc1)F)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mammal (species unspecified) LD50 oral 450mg/kg (450mg/kg)   European Patent Application. Vol. #0180290,
mouse LD50 oral 414mg/kg (414mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 47, Pg. 648, 1997.
rat LD50 oral 134mg/kg (134mg/kg)   Drugs of the Future. Vol. 14, Pg. 24, 1989.