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Substance Name: Seratrodast [USAN:INN]
RN: 112665-43-7
UNII: 4U58JM421N
InChIKey: ZBVKEHDGYSLCCC-UHFFFAOYSA-N
Note
- Has thromboxane A2 & prostaglandin H2 receptor antagonistic action.
Molecular Formula
- C22-H26-O4
Molecular Weight
- 354.443
Classification Codes
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Asthmatic (Thromboxane Receptor Antagonist)
- Anti-Asthmatic Agents
- Anti-Inflammatory (Nonantihistaminic)
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Drug / Therapeutic Agent
- Hormone Antagonists
- Hormones, Hormone Substitutes, and Hormone Antagonists
- Peripheral Nervous System Agents
- Prostaglandin Antagonists
- Reproductive Effect
- Respiratory System Agents
- Sensory System Agents
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Names and Synonyms
Name of Substance
- Seratrodast
- Seratrodast [USAN:INN]
Synonyms
- (+-)-7-(3,5,6-Trimethyl-1,4-benzoquinon-2-yl)-7-phenylheptanoic acid
- A 73001
- A-73001
- AA-2414
- Abbott 73001
- Abbott-73001
- ABT 001
- ABT-001
- CCRIS 8939
- NSC 759640
- Seratrodast
- UNII-4U58JM421N
Systematic Names
- (+-)-2,4,5-Trimethyl-3,6-dioxo-zeta-phenyl-1,4-cyclohexadiene-1-heptanoic acid
- Benzeneheptanoic acid, zeta-(2,4,5-trimethyl-3,6-dioxo-1,4-cyclohexadien-1-yl)-, (+-)-
Registry Numbers
CAS Registry Number
- 112665-43-7
FDA UNII
- 4U58JM421N
Other Registry Number
- 103186-19-2
System Generated Number
- 0112665437
Structure Descriptors
InChI
InChI=1S/C22H26O4/c1-14-15(2)22(26)20(16(3)21(14)25)18(17-10-6-4-7-11-17)12-8-5-9-13-19(23)24/h4,6-7,10-11,18H,5,8-9,12-13H2,1-3H3,(H,23,24)InChIKey
ZBVKEHDGYSLCCC-UHFFFAOYSA-NSmiles
CC1=C(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
monkey | LD | oral | > 2gm/kg (2000mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 394, 1996. |
mouse | LD50 | intraperitoneal | 1100mg/kg (1100mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. | |
mouse | LD50 | oral | 1520mg/kg (1520mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. | |
mouse | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. | |
rat | LD50 | intraperitoneal | 1350mg/kg (1350mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. | |
rat | LD50 | oral | 3750mg/kg (3750mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. | |
rat | LD50 | subcutaneous | > 5gm/kg (5000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995. |