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Substance Name: Zenarestat [USAN:INN]
RN: 112733-06-9
UNII: 180C9PJ8JT
InChIKey: SXONDGSPUVNZLO-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Treatment of Diabetic Neuropathy (Aldose Reductase Inhibitor)

Molecular Formula

  • C17-H11-Br-Cl-F-N2-O4

Molecular Weight

  • 441.639
 
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Names and Synonyms

Name of Substance

  • FR 74366
  • Zenarestat [USAN:INN]

Synonyms

  • 2-(7-Chloro-3-(4-bromo-2-fluorobenzyl)-1,2,3,4-tetrahydro-2,4-dioxoquinazolin)-1-acetic acid
  • 3-((4-Bromo-2-fluorophenyl)methyl)-7-chloro-3,4-dihydro-2,4-dioxo-1(2H)-quinazolineacetic acid
  • CI 1014
  • CI-1014
  • FK 366
  • FK-366
  • FR 74366
  • FR-74366
  • UNII-180C9PJ8JT
  • Zenarestat
  • Zenarestatum
  • Zenarestatum [INN-Latin]

Systematic Names

  • 1(2H)-Quinazolineacetic acid, 3,4-dihydro-3-((4-bromo-2-fluorophenyl)methyl)-7-chloro-2,4-dioxo-
  • 3-(4-Bromo-2-fluorobenzyl)-7-chloro-3,4-dihydro-2,4-dioxo-1(2H)-quinazolineacetic acid

Registry Numbers

CAS Registry Number

  • 112733-06-9

FDA UNII

  • 180C9PJ8JT

System Generated Number

  • 0112733069

Structure Descriptors

InChI

1S/C17H11BrClFN2O4/c18-10-2-1-9(13(20)5-10)7-22-16(25)12-4-3-11(19)6-14(12)21(17(22)26)8-15(23)24/h1-6H,7-8H2,(H,23,24)

InChIKey

SXONDGSPUVNZLO-UHFFFAOYSA-N

Smiles

c1(c2c(cc(cc2)Cl)n(CC(O)=O)c(=O)n1Cc1c(cc(cc1)Br)F)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 oral 4250mg/kg (4250mg/kg)   United States Patent Document. Vol. #4931440,