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Substance Name: AS 4370
RN: 112885-42-4
UNII: MF497J489P
InChIKey: HUZTYZBFZKRPFG-UHFFFAOYSA-N

Note

  • Gastrokinetic agent free of dopamine D2 receptor antagonist properties.

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C21-H25-Cl-F-N3-O3.C6-H8-O7

Molecular Weight

  • 614.02
 
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Names and Synonyms

Name of Substance

  • AS 4370

Synonyms

  • (+-)-4-Amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide citrate
  • AS 4370
  • Mosapride citrate
  • UNII-MF497J489P

Systematic Name

  • Benzamide, 4-amino-5-chloro-2-ethoxy-N-((4-((4-fluorophenyl)methyl)-2-morpholinyl)methyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1)

Registry Numbers

CAS Registry Number

  • 112885-42-4

FDA UNII

  • MF497J489P

System Generated Number

  • 0112885424

Molecular Formulas

Molecular Formula

  • C21-H25-Cl-F-N3-O3.C6-H8-O7

Molecular Formula Fragments

  • C21-H25-Cl-F-N3-O3
  • C6-H8-O7
  • COMPONENT

Structure Descriptors

InChI

1S/C21H25ClFN3O3.C6H8O7/c1-2-28-20-10-19(24)18(22)9-17(20)21(27)25-11-16-13-26(7-8-29-16)12-14-3-5-15(23)6-4-14;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-6,9-10,16H,2,7-8,11-13,24H2,1H3,(H,25,27);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChIKey

HUZTYZBFZKRPFG-UHFFFAOYSA-N

Smiles

c1(cc(c(OCC)cc1N)C(NC[C@@H]1OCC[N@@](C1)Cc1ccc(cc1)F)=O)Cl.OC(CC(C(O)=O)(CC(O)=O)O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 400mg/kg (400mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 3343, 1993.
mouse LD50 intraperitoneal 914mg/kg (914mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 3343, 1993.
mouse LD50 oral > 3gm/kg (3000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 3343, 1993.
mouse LD50 subcutaneous > 1gm/kg (1000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 3343, 1993.
rat LD50 intraperitoneal > 1gm/kg (1000mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LIVER: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 3343, 1993.
rat LD50 oral > 3gm/kg (3000mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 3343, 1993.
rat LD50 subcutaneous > 1gm/kg (1000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 3343, 1993.