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Substance Name: 7-Hydroxystaurosporine
RN: 112953-11-4
UNII: 7BU5H4V94A
InChIKey: PBCZSGKMGDDXIJ-HQCWYSJUSA-N

Classification Codes

  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Natural Product
  • Protein Kinase Inhibitors

Molecular Formula

  • C28-H26-N4-O4

Molecular Weight

  • 482.5374
 
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Names and Synonyms

Name of Substance

  • 7-Hydroxystaurosporine

Synonyms

  • 7-Hydroxystaurosporine
  • NSC 638850
  • UCN 01
  • UCN-01
  • UCN01
  • UNII-7BU5H4V94A

Systematic Names

  • 8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)triinden-1-one, 2,3,9,10,11,12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)-
  • 9,13-Epoxy-1H,9H-diindolo(1,2,3-gh:3',2',1'-lm)pyrrolo(3,4-j)(1,7)benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-3-hydroxy-10-methoxy-9-methyl-11-(methylamino)-, (3-alpha,9-beta,10-alpha,11-alpha,13-beta)-(+)-

Registry Numbers

CAS Registry Number

  • 112953-11-4

FDA UNII

  • 7BU5H4V94A

System Generated Number

  • 0112953114

Structure Descriptors

InChI

1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27-,28+/m1/s1

InChIKey

PBCZSGKMGDDXIJ-HQCWYSJUSA-N

Smiles

CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n3c4ccccc4c5c6[C@@H](O)NC(=O)c6c7c8ccccc8n2c7c35

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 25mg/kg (25mg/kg)   Journal of Antibiotics. Vol. 42, Pg. 571, 1989.