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Substance Name: Dosulepin [INN:BAN]
RN: 113-53-1
UNII: W13O82Z7HL
InChIKey: PHTUQLWOUWZIMZ-GZTJUZNOSA-N

Note

  • A tricyclic antidepressant with some tranquilizing action.

Molecular Formula

  • C19-H21-N-S

Molecular Weight

  • 295.4479
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic Uptake Inhibitors
  • Antidepressive Agents
  • Antidepressive Agents, Tricyclic
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Human Data
  • Membrane Transport Modulators
  • Mutation Data
  • Neurotransmitter Agents
  • Neurotransmitter Uptake Inhibitors
  • Psychotropic Drugs
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Dosulepin [INN:BAN]
  • Dothiepin

MeSH Heading

  • Dothiepin

Synonyms

  • 11-(3-Dimethylaminopropylidene)-6,11-dihydrodibenzo(b,e)thiepin
  • 3-(6,11-Dihydrodibenzo(b,e)thiepin-11-yliden)-N,N-dimethylpropylamin
  • 3-(6H-Dibenzo(b,e)thiepin-11-yliden)-N,N-dimethylpropylamin
  • 3-Dibenzo(b,e)thiepin-11(6H)-ylidene-N,N-dimethyl-1-propamine
  • Dosulepin
  • Dosulepina
  • Dosulepina [INN-Spanish]
  • Dosulepine
  • Dosulepine [INN-French]
  • Dosulepinum
  • Dosulepinum [INN-Latin]
  • Dothiepin
  • EINECS 204-031-2
  • HSDB 7181
  • IZ 914
  • N,N-Dimethyldibenzo(b,e)thiepin-delta-sup(11(6H),gamma)propylamine
  • Prothiaden spofa
  • UNII-W13O82Z7HL

Systematic Names

  • 1-Propanamine, 3-dibenzo(b,e)thiepin-11(6H)-ylidene-N,N-dimethyl- (9CI)
  • Dosulepin
  • Propylamine, N,N-dimethyl-3-(dibenzo(b,e)thiepin-delta-sup(11(6H),gamma))-

Registry Numbers

CAS Registry Number

  • 113-53-1

FDA UNII

  • W13O82Z7HL

Related Registry Number

  • 897-15-4 (hydrochloride)

System Generated Number

  • 0000113531

Structure Descriptors

InChI

1S/C19H21NS/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19/h3-6,8-12H,7,13-14H2,1-2H3/b17-11+

InChIKey

PHTUQLWOUWZIMZ-GZTJUZNOSA-N

Smiles

CN(C)CC\C=C\1/c2ccccc2CSc3ccccc13

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo oral 2143ug/kg/8D- (2.143mg/kg) BEHAVIORAL: SLEEP

BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Human Psychopharmacology. Vol. 12, Pg. 119, 1997.
human TDLo oral 3214ug/kg/12D (3.214mg/kg) BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS Human Psychopharmacology. Vol. 12, Pg. 337, 1997.
infant TDLo oral 100mg/kg (100mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

BEHAVIORAL: COMA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
British Medical Journal. Vol. 288, Pg. 1800, 1984.
mouse LD50 intravenous 31mg/kg (31mg/kg)   Collection of Czechoslovak Chemical Communications. Vol. 32, Pg. 2854, 1967.
mouse LD50 oral 320mg/kg (320mg/kg)   Journal of International Medical Research. Vol. 13, Pg. 77, 1985.
rat LD50 oral 450mg/kg (450mg/kg)   Journal of International Medical Research. Vol. 13, Pg. 77, 1985.
women TDLo oral 4500ug/kg (4.5mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) British Medical Journal. Vol. 2, Pg. 97, 1977.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 56 deg C   EXP
log P (octanol-water) 4.49 (none)   EXP
Water Solubility 1.510 mg/L 25 EST
Vapor Pressure 4.28E-07 mm Hg 25 EST
Henry's Law Constant 1.36E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.91E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.