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Substance Name: Chlorprothixene [USAN:USP:INN:BAN:JAN]
RN: 113-59-7
UNII: 9S7OD60EWP
InChIKey: WSPOMRSOLSGNFJ-AUWJEWJLSA-N

Note

  • A thioxanthine with effects similar to the phenothiazine antipsychotics.

Molecular Formula

  • C18-H18-Cl-N-S

Molecular Weight

  • 315.8662
 

Classification Codes

  • Antipsychotic
  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Dopamine Agents
  • Dopamine Antagonists
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Reproductive Effect
  • Tranquilizing Agents

Names and Synonyms

Name of Substance

  • Chlorprothixene
  • Chlorprothixene [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Chlorprothixene

Synonyms

  • (Z)-2-Chloro-9-(omega-dimethylaminopropylidene)thioxanthene
  • (Z)-2-Chloro-N,N-dimethylthioxanthene-delta(sup 9,gamma)-propylamine
  • 1-Propanamine, 3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-, (Z)-
  • Chlorprothixen
  • Chlorprothixene
  • Chlorprothixenum
  • Chlorprothixenum [INN-Latin]
  • Chlorprotixen
  • Chlorprotixene
  • Chlothixen
  • cis-2-Chloro-9-(3-dimethylaminopropylidene)thioxanthene
  • Clorprotisene
  • Clorprotisene [DCIT]
  • Clorprotixeno
  • Clorprotixeno [INN-Spanish]
  • CPT
  • CPX
  • EINECS 204-032-8
  • HSDB 2808
  • Iaractan
  • MK 184
  • N 714
  • N 714C
  • N-714
  • NSC 18720
  • Paxyl
  • Rentovet
  • Ro 4-0403
  • Taractan
  • Tarasan
  • Traquilan
  • Trictal
  • Truxal
  • Truxaletten
  • Truxil
  • UNII-9S7OD60EWP
  • Vetacalm

Systematic Names

  • 1-Propanamine, 3-(2-chloro-9H-thioxanthen-9-ylidene)-N,N-dimethyl-, (Z)-
  • Chlorprothixene
  • Thioxanthene-delta(sup 9),gamma-propylamine, 2-chloro-N,N-dimethyl-, (Z)-
  • Thioxanthene-delta9,gamma-propylamine, 2-chloro-N,N-dimethyl-, (Z)- (8CI)

Registry Numbers

CAS Registry Number

  • 113-59-7

FDA UNII

  • 9S7OD60EWP

Other Registry Number

  • 4695-61-8

System Generated Number

  • 0000113597

Structure Descriptors

InChI

1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3/b14-7-

InChIKey

WSPOMRSOLSGNFJ-AUWJEWJLSA-N

Smiles

CN(C)CC\C=C/1\c2ccccc2Sc3ccc(Cl)cc13

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man LDLo oral 7mg/kg (7mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: MUSCLE WEAKNESS
Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 596, 1964.
mouse LD50 intraperitoneal 56200ug/kg (56.2mg/kg)   Cancer Research. Vol. 47, Pg. 5944, 1987.
mouse LD50 intravenous 36mg/kg (36mg/kg)   Drugs in Japan Vol. -, Pg. 373, 1990.
mouse LD50 oral 50100ug/kg (50.1mg/kg)   Cancer Research. Vol. 47, Pg. 5944, 1987.
rabbit LD50 oral 182mg/kg (182mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 33, 1969.
rat LD50 oral 200mg/kg (200mg/kg)   Drugs in Japan Vol. 6, Pg. 252, 1982.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 97.5 deg C   EXP
log P (octanol-water) 5.18 (none)   EXP
Water Solubility 0.295 mg/L 25 EST
Vapor Pressure 2.37E-07 mm Hg 25 EST
Henry's Law Constant 2.50E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.83E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.