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Substance Name: Chlorpheniramine maleate [USP:JAN]
RN: 113-92-8
UNII: V1Q0O9OJ9Z
InChIKey: DBAKFASWICGISY-BTJKTKAUSA-N
Note
- A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.
Molecular Formula
- C16-H19-Cl-N2.C4-H4-O4
Molecular Weight
- 390.8647
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- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Antihistaminic
- Drug / Therapeutic Agent
- Mutation Data
- Reproductive Effect
- Tumor Data
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Names and Synonyms
Name of Substance
- Chlorpheniramine maleate [USP:JAN]
Synonyms
- 1-(N,N-Dimethylamino)-3-(p-chlorophenyl-3-alpha-pyridyl)propane maleate
- 1-(p-Chlorphenyl)-1-(2-pyridyl)-3-dimethylaminopropan maleat
- 1-(p-Chlorphenyl)-1-(2-pyridyl)-3-dimethylaminopropan maleat [German]
- 1-p-Chlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
- 2-(p-Chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine maleate (1:1)
- Allerclor
- Allergin
- Alunex
- Antagonate
- C-Meton
- Carbinoxamide maleate
- CCRIS 1418
- Chlor-trimeton
- Chlor-trimeton 12 hour
- Chlor-Trimeton Allergy
- Chlor-Trimeton Injection
- Chlor-Trimeton OD
- Chlor-Trimeton Repetabs, Syrup, and Tablets
- Chlor-tripolon
- Chlormene
- Chloroprophenpyridamine maleate
- Chlorpheniramine maleate
- Chlorpheniramine maleate OROS Tablets
- Dehist
- dl-2-(p-Chloro-alpha-2-(dimethylamino)ethylbenzyl)pyridine maleate
- dl-Chlorpheniramine maleate
- Efidac 24 chlorpheniramine maleate
- EINECS 204-037-5
- Histadur dura-tabs
- Ibioton
- Kloromin
- Lorphen
- M.P. chlorcaps T.D.
- Medique chlorphen
- NCI-C55265
- Neorestamin
- Phenalin
- Phenetron
- Piriex
- Piriton
- Polaronil
- Polaronil [German]
- Pyridamal 100
- Pyridamal-100
- Synistamin
- Teldrin
- UNII-V1Q0O9OJ9Z
Systematic Names
- 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)
- 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (Z)-2-butenedioate (1:1)
- Chlorphenamine hydrogen maleate
- Chlorpheniramine maleate
- Pyridine, 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-, maleate (1:1)
Superlist Name
- Chlorpheniramine maleate
Mixture Names
- A.R.M.
- Alka-seltzer plus
- Allerest
- Anaplex HD
- Azimycin (Veterinary)
- Bayer Select Allergy-Sinus
- Bayer Select Flu Relief
- Brexin L.A.
- Cerose-DM
- Chlor-trimeton 12 hour
- Chlor-Trimeton Decongestant
- Chlor-Trimeton Sinus
- Co-Pyronil 2
- Comhist
- Contac
- Contac 12 Hour Caplets
- Contac 12 Hour Capsules
- Contac Severe Cold Formula Maximum Strength
- Corfen
- Coricidin
- Coricidin D
- Coricidin Sinus
- Corilin
- Deconamine
- Demazin
- Demilets
- Diathal (Veterinary)
- Dristan Cold Maximum Strength Multi-Symptom
- Duohist
- Histalet Forte
- Histaspan-D
- Histaspan-Plus
- Hycomine Compound
- Intensin
- Lohist
- Metrevet (Veterinary)
- Naldecon
- Nasohist
- Novahistine
- Ornade
- PediaCare Cold Formula
- PediaCare Cough-Cold Formula
- Phenylhistine DH
- PV Tussin Syrup
- Rhinex D-Lay Tablets
- Robitussin Pediatric Night Relief
- Ru-Tuss Capsules
- Ru-Tuss Liquid
- Ru-Tuss Tablets
- Sildec PE
- Sine off
- Sine-Off Maximum Strength Allergy/Sinus
- Sine-Off Sinus Medicine Caplets
- Sine-Off Sinus Medicine Tablets-Aspirin Formula
- Sonahist
- Sudafed Plus
- Teldrin Timed-Release Allergy Capsules
- TheraFlu
- Triaminic
- Trind
- Trind-DM
- Tussar DM
- Tussar SF
- Tussar-2
- Tylenol Allergy Sinus
- Tylenol Children's Cold Tablets
- Tylenol Children's Cough Cold Chewable Tablets
- Tylenol Cold and Flu Multi-Symptom
- Tylenol Cold Medication Caplets, Liquid and Tablets
- Viro-Med
- Zodryl AC 25
- Zodryl AC 30
- Zodryl AC 40
- Zodryl AC 50
- Zodryl AC 60
- Zodryl AC 80
Registry Numbers
CAS Registry Number
- 113-92-8
FDA UNII
- V1Q0O9OJ9Z
Other Registry Number
- 7054-11-7
Related Registry Number
- 25523-97-1 (Parent)
System Generated Number
- 0000113928
Molecular Formulas
Molecular Formula
- C16-H19-Cl-N2.C4-H4-O4
Molecular Formula Fragments
- C16-H19-Cl-N2
- C4-H4-O4
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-InChIKey
DBAKFASWICGISY-BTJKTKAUSA-NSmiles
CN(C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - wild | LD50 | oral | 75mg/kg (75mg/kg) | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. | |
dog | LD50 | intravenous | 97600ug/kg (97.6mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955. |
guinea pig | LD50 | intravenous | 68mg/kg (68mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958. | |
guinea pig | LD50 | oral | 198mg/kg (198mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR | Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955. |
guinea pig | LD50 | subcutaneous | 101mg/kg (101mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR | Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955. |
mouse | LD50 | intraperitoneal | 76700ug/kg (76.7mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955. |
mouse | LD50 | intravenous | 26100ug/kg (26.1mg/kg) | Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972. | |
mouse | LD50 | oral | 130mg/kg (130mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1644, 1978. | |
mouse | LD50 | subcutaneous | 104mg/kg (104mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955. |
rat | LD50 | oral | 306mg/kg (306mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 1371, 1978. |
rat | LD50 | subcutaneous | 365mg/kg (365mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. |