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Substance Name: Chlorpheniramine maleate [USP:JAN]
RN: 113-92-8
UNII: V1Q0O9OJ9Z
InChIKey: DBAKFASWICGISY-BTJKTKAUSA-N

Note

  • A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.

Molecular Formula

  • C16-H19-Cl-N2.C4-H4-O4

Molecular Weight

  • 390.8647
 

Classification Codes

  • Antihistaminic
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect
  • Tumor Data

Names and Synonyms

Name of Substance

  • Chlorpheniramine maleate [USP:JAN]

Synonyms

  • 1-(N,N-Dimethylamino)-3-(p-chlorophenyl-3-alpha-pyridyl)propane maleate
  • 1-(p-Chlorphenyl)-1-(2-pyridyl)-3-dimethylaminopropan maleat
  • 1-(p-Chlorphenyl)-1-(2-pyridyl)-3-dimethylaminopropan maleat [German]
  • 1-p-Chlorophenyl-1-(2-pyridyl)-3-dimethylaminopropane maleate
  • 2-(p-Chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine maleate (1:1)
  • Allerclor
  • Allergin
  • Alunex
  • Antagonate
  • C-Meton
  • Carbinoxamide maleate
  • CCRIS 1418
  • Chlor-trimeton
  • Chlor-trimeton 12 hour
  • Chlor-Trimeton Allergy
  • Chlor-Trimeton Injection
  • Chlor-Trimeton OD
  • Chlor-Trimeton Repetabs, Syrup, and Tablets
  • Chlor-tripolon
  • Chlormene
  • Chloroprophenpyridamine maleate
  • Chlorpheniramine maleate
  • Chlorpheniramine maleate OROS Tablets
  • Dehist
  • dl-2-(p-Chloro-alpha-2-(dimethylamino)ethylbenzyl)pyridine maleate
  • dl-Chlorpheniramine maleate
  • Efidac 24 chlorpheniramine maleate
  • EINECS 204-037-5
  • Histadur dura-tabs
  • Ibioton
  • Kloromin
  • Lorphen
  • M.P. chlorcaps T.D.
  • Medique chlorphen
  • NCI-C55265
  • Neorestamin
  • Phenalin
  • Phenetron
  • Piriex
  • Piriton
  • Polaronil
  • Polaronil [German]
  • Pyridamal 100
  • Pyridamal-100
  • Synistamin
  • Teldrin
  • UNII-V1Q0O9OJ9Z

Systematic Names

  • 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (2Z)-2-butenedioate (1:1)
  • 2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (Z)-2-butenedioate (1:1)
  • Chlorphenamine hydrogen maleate
  • Chlorpheniramine maleate
  • Pyridine, 2-(p-chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-, maleate (1:1)

Superlist Name

  • Chlorpheniramine maleate

Mixture Names

  • A.R.M.
  • Alka-seltzer plus
  • Allerest
  • Anaplex HD
  • Azimycin (Veterinary)
  • Bayer Select Allergy-Sinus
  • Bayer Select Flu Relief
  • Brexin L.A.
  • Cerose-DM
  • Chlor-trimeton 12 hour
  • Chlor-Trimeton Decongestant
  • Chlor-Trimeton Sinus
  • Co-Pyronil 2
  • Comhist
  • Contac
  • Contac 12 Hour Caplets
  • Contac 12 Hour Capsules
  • Contac Severe Cold Formula Maximum Strength
  • Corfen
  • Coricidin
  • Coricidin D
  • Coricidin Sinus
  • Corilin
  • Deconamine
  • Demazin
  • Demilets
  • Diathal (Veterinary)
  • Dristan Cold Maximum Strength Multi-Symptom
  • Duohist
  • Histalet Forte
  • Histaspan-D
  • Histaspan-Plus
  • Hycomine Compound
  • Intensin
  • Lohist
  • Metrevet (Veterinary)
  • Naldecon
  • Nasohist
  • Novahistine
  • Ornade
  • PediaCare Cold Formula
  • PediaCare Cough-Cold Formula
  • Phenylhistine DH
  • PV Tussin Syrup
  • Rhinex D-Lay Tablets
  • Robitussin Pediatric Night Relief
  • Ru-Tuss Capsules
  • Ru-Tuss Liquid
  • Ru-Tuss Tablets
  • Sildec PE
  • Sine off
  • Sine-Off Maximum Strength Allergy/Sinus
  • Sine-Off Sinus Medicine Caplets
  • Sine-Off Sinus Medicine Tablets-Aspirin Formula
  • Sonahist
  • Sudafed Plus
  • Teldrin Timed-Release Allergy Capsules
  • TheraFlu
  • Triaminic
  • Trind
  • Trind-DM
  • Tussar DM
  • Tussar SF
  • Tussar-2
  • Tylenol Allergy Sinus
  • Tylenol Children's Cold Tablets
  • Tylenol Children's Cough Cold Chewable Tablets
  • Tylenol Cold and Flu Multi-Symptom
  • Tylenol Cold Medication Caplets, Liquid and Tablets
  • Viro-Med
  • Zodryl AC 25
  • Zodryl AC 30
  • Zodryl AC 40
  • Zodryl AC 50
  • Zodryl AC 60
  • Zodryl AC 80

Registry Numbers

CAS Registry Number

  • 113-92-8

FDA UNII

  • V1Q0O9OJ9Z

Other Registry Number

  • 7054-11-7

Related Registry Number

  • 25523-97-1 (Parent)

System Generated Number

  • 0000113928

Molecular Formulas

Molecular Formula

  • C16-H19-Cl-N2.C4-H4-O4

Molecular Formula Fragments

  • C16-H19-Cl-N2
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-

InChIKey

DBAKFASWICGISY-BTJKTKAUSA-N

Smiles

CN(C)CCC(c1ccc(cc1)Cl)c2ccccn2.C(=C\C(=O)O)\C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 75mg/kg (75mg/kg)   Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.
dog LD50 intravenous 97600ug/kg (97.6mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
guinea pig LD50 intravenous 68mg/kg (68mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958.
guinea pig LD50 oral 198mg/kg (198mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
guinea pig LD50 subcutaneous 101mg/kg (101mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
mouse LD50 intraperitoneal 76700ug/kg (76.7mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
mouse LD50 intravenous 26100ug/kg (26.1mg/kg)   Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972.
mouse LD50 oral 130mg/kg (130mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1644, 1978.
mouse LD50 subcutaneous 104mg/kg (104mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955.
rat LD50 oral 306mg/kg (306mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 1371, 1978.
rat LD50 subcutaneous 365mg/kg (365mg/kg)   Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.