Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Penicillin G potassium [USP]
RN: 113-98-4
UNII: VL775ZTH4C
InChIKey: IYNDLOXRXUOGIU-LQDWTQKMSA-M

Classification Codes

  • Antibacterial
  • Mutation Data

Molecular Formula

  • C16-H18-N2-O4-S.K

Molecular Weight

  • 372.4843
 

Names and Synonyms

Name of Substance

  • Penicillin G potassium [USP]

Synonyms

  • Benzylpenicillin potassium
  • Benzylpenicillin potassium salt
  • Benzylpenicilline potassique
  • Benzylpenicilline potassique [DCF]
  • Benzylpenicillinic acid potassium salt
  • C-Cillin
  • Capicillin
  • Cillin
  • Cilloral potassium salt
  • Cintrisul
  • Cosmopen potassium salt
  • Cristapen
  • EINECS 204-038-0
  • Eskacillin
  • Falapen
  • Forpen
  • Hipercilina
  • Hyasorb
  • Hylenta
  • Lemopen
  • Liquapen
  • Megacillin tablets
  • Monopen
  • Monopotassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate
  • Notaral
  • Novocillin vet.
  • NSC 131815
  • Paclin G
  • Penalev
  • Penicillin
  • Penicillin G K
  • Penicillin G potassium
  • Penicillin G potassium in plastic container
  • Penicillin potassium G, crystalline
  • Penicillin-2
  • Penisem
  • Pentid
  • Pentids
  • Pentids '200'
  • Pentids '250'
  • Pentids '400'
  • Pentids '800'
  • Pfizerpen
  • Pfizerpen G
  • Potassium 6-(phenylacetamido)penicillanate
  • Potassium benzylpenicillin
  • Potassium benzylpenicillin G
  • Potassium benzylpenicillinate
  • Potassium penicillin G
  • Potassium salt of benzylpenicillin
  • Qidpen G
  • Scotcil
  • SK-Penicillin G
  • Sugracillin
  • Tabilin
  • Tu Cillin
  • UNII-VL775ZTH4C
  • Van-Pen-G

Systematic Names

  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6- (2-phenylacetamido)-, monopotassium salt
  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((2-phenylacetyl)amino)- (2S,5R,6R)-, potassium salt (1:1)
  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)- (2S,5R,6R)-, monopotassium salt
  • 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)-, monopotassium salt, (2S-(2alpha,5alpha,6beta))-
  • AI3-50119
  • Potassium (2S-(2alpha,5alpha,6beta))-3,3-dimethyl-7-oxo-6-(phenylacetamido)-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate

Registry Numbers

CAS Registry Number

  • 113-98-4

FDA UNII

  • VL775ZTH4C

Other Registry Number

  • 55878-83-6

Related Registry Number

  • 61-33-6 (Parent)

System Generated Number

  • 0000113984

Molecular Formulas

Molecular Formula

  • C16-H18-N2-O4-S.K

Molecular Formula Fragments

  • C16-H18-N2-O4-S
  • COMPONENT
  • K

Structure Descriptors

InChI

1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1

InChIKey

IYNDLOXRXUOGIU-LQDWTQKMSA-M

Smiles

CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)Cc3ccccc3)C(=O)[O-])C.[K+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intramuscular 1180mg/kg (1180mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
guinea pig LD50 intraperitoneal 374mg/kg (374mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
guinea pig LD50 intravenous 303mg/kg (303mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 306, 1970.
guinea pig LD50 oral 382mg/kg (382mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Antibiotics and Chemotherapy Vol. 11, Pg. 276, 1961.
mouse LD50 intramuscular > 2gm/kg (2000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
mouse LD50 intraperitoneal > 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
mouse LD50 intravenous 240mg/kg (240mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
mouse LD50 oral 6257mg/kg (6257mg/kg) BEHAVIORAL: EXCITEMENT Archives Internationales de Pharmacodynamie et de Therapie. Vol. 125, Pg. 83, 1960.
mouse LDLo intracrebral 2mg/kg (2mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Planta Medica. Vol. 49, Pg. 103, 1983.
rabbit LD50 oral 5848mg/kg (5848mg/kg)   Antibiotics and Chemotherapy Vol. 10, Pg. 376, 1960.
rabbit LD50 oral 5848mg/kg (5848mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
Antibiotics and Chemotherapy Vol. 10, Pg. 376, 1960.
rat LD50 intramuscular > 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
rat LD50 intraperitoneal > 2gm/kg (2000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
rat LD50 intravenous 243mg/kg (243mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Antibiotics Annual. Vol. 3, Pg. 534, 1955/1956.
rat LD50 oral 8900mg/kg (8900mg/kg)   Antibiotics and Chemotherapy Vol. 12, Pg. 249, 1962.
rat LD50 subcutaneous 11250mg/kg (11250mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Toxicology and Applied Pharmacology. Vol. 9, Pg. 445, 1966.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -3.010 (none)   EST
Atmospheric OH Rate Constant 6.64E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.